癌毒病机科学内涵的现代诠释

程海波; 周仲瑛

doi:10.14148/j.issn.1672-0482.2021.0637

癌毒病机科学内涵的现代诠释

doi: 10.14148/j.issn.1672-0482.2021.0637

程海波^{1, 2, ,},
周仲瑛¹

1.
南京中医药大学第一临床医学院，江苏南京 210023
2.
江苏省中医药防治肿瘤协同创新中心，江苏南京 210023

基金项目:

国家自然科学基金重点项目 81930117

国家重点研发计划 2017YFC1700602

详细信息

作者简介:
程海波 1975年生，教授，主任中医师，博士生导师，美国哈佛大学医学院博士后。国家“万人计划”领军人才，国家中医药领军人才“岐黄学者”，科技部中青年科技创新领军人才，江苏省有突出贡献中青年专家。现任江苏省中医药防治肿瘤协同创新中心主任，兼任中华中医药学会肿瘤分会副主任委员。长期从事中医药防治肿瘤研究，先后主持国家自然科学基金重点项目、国家重点研发计划项目等省部级项目20余项，发表学术论文200余篇，其中SCI论文40余篇，主编行业规划教材1部、学术著作2部，授权发明专利13项，获教育部科技进步奖一等奖、中华中医药学会科学技术奖一等奖

通讯作者:
程海波，男，教授，主要从事中医癌毒病机理论的研究，E-mail: hbcheng@njucm.edu.cn

中图分类号: R273
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- 被引次数: 0
出版历程
- 收稿日期: 2021-08-20
- 网络出版日期: 2021-12-21
- 刊出日期: 2021-09-10
- 发布日期: 2021-09-15

Modern Interpretation of the Scientific Connotation of the Pathogenesis of Cancerous Toxin

CHENG Hai-bo^{1, 2
, ,},
ZHOU Zhong-ying¹

1.
The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China
2.
Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing, 210023, China

摘要

摘要: 癌毒病机理论是程海波教授团队创建的中医肿瘤创新病机理论，近年来被广泛应用于指导恶性肿瘤的临床辨治，并取得了较好的临床疗效。癌毒是导致恶性肿瘤的一类特异性致病因子，是恶性肿瘤发生、发展的关键病机。团队长期围绕癌毒病机的科学内涵开展研究，通过探讨癌毒病机理论与肿瘤微环境的关系、癌毒病机与肿瘤微环境中的特异性致病物质的相关性，提出癌毒的科学内涵是肿瘤微环境中影响肿瘤发生、发展的一类特异性致病物质，炎症因子、乳酸、血管生成因子、免疫抑制因子、外泌体非编码RNA等可能是癌毒病机的生物学基础。结合现代肿瘤学研究进展，诠释癌毒病机的科学内涵，为进一步推广癌毒病机理论及临床应用提供科学依据。
- 癌毒 /
- 病机理论 /
- 恶性肿瘤 /
- 肿瘤微环境 /
- 科学内涵
Abstract: Pathogenesis theory of cancerous toxin is an innovative theory of traditional Chinese medicine oncology developed by the team, which has been widely used to guide the clinical differentiation and treatment for malignant tumors in recent years, and has achieved good clinical efficacy. Cancerous toxin is a specific pathogenic factor that causes malignant tumors and is the key pathogenesis for the development of malignant tumors. The team has been conducting research on the scientific connotation of pathogenesis of cancerous toxin for a long time. Through exploring the relationship between pathogenesis theory of cancerous toxin and tumor microenvironment as well as the correlation between pathogenesis of cancerous toxin and specific morbid substances in tumor microenvironment, the team comes up with that the scientific connotation of cancerous toxin is a specific morbid substance (affecting tumor genesis and development) in tumor microenvironment. In addition, the team also believes that inflammatory factors, lactic acid, angiogenic factors, immunosuppressive factors, and non-coding RNAs may be the biological basis for the pathogenesis of cancerous toxin. Applying modern oncology research progress, we interpret the scientific connotation of the pathogenesis of cancerous toxin, and provide scientific basis for further promotion of the theory of cancerous toxin and its clinical application.
- cancerous toxin /
- pathogenesis theory /
- malignant tumor /
- tumor microenvironment /
- scientific connotation

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图 1 中医癌毒肿瘤理论的现代生物学内涵

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