Progress on Gut Microbiota-Regulated Bone Metabolism Imbalance and Implications for Chinese Medicine Intervention
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摘要: 肠道菌群是人体内种类最多、密度最大的微生物群落的总称。肠道菌群可通过与宿主共代谢，调控宿主多种生理功能、维持体内免疫平衡，进而维护人体健康。近年来的研究结果表明，肠道菌群与宿主的骨代谢密切相关。在多种病理状态或药物等引起肠道菌群改变后，可引起继发性的病理性骨丢失。随着高通量测序、基因敲除、无菌鼠繁殖等新技术的发展，越来越多的证据表明肠道菌群可通过直接调控，或通过内源性物质代谢调控，或改变与骨代谢相关的激素水平影响宿主的骨代谢。拟在全面阐述肠道菌群与骨代谢关系的基础上，总结肠道菌群调控骨代谢的潜在途径和常见中药的作用机制，并探讨其对主要骨代谢异常相关疾病在临床治疗和药物靶点研究中的启示。Abstract: Gut microbiota has the most category and highest density among all microbial habitats in human body. They can regulate human physiological functions and immune status through gut microbiota-host metabolism and then maintain our healthy. Recently, accumulating clinical researches and preclinical studies have reported that gut microbiota can regulate bone metabolism through various ways. For example, alterations in microbiota composition induced by a variety of pathological states and medicine, especially the antibiotics, may contribute to pathological bone loss. With the development of some new techniques such as high-throughput sequencing, gene knockout and germ-free mice, the recent studies implicated that gut microbiota can regulate bone metabolism balance through direct regulation, the metabolism of endogenous substances and the alterations of related hormones. This review describes recent data uncovering the relationship between gut microbiota and bone metabolism, with a focus on potential regulating pathways and Traditional Chinese Medicine intervention. The implications for treatment of bone metabolism disorders such as osteoporosis and drug target research are discussed as well.
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Key words:
- gut microbiota /
- bone metabolism /
- herbal drug intervention
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