海洋天然产物中α-葡萄糖苷酶抑制剂研究进展

朱月霞; 邵仲柏; 吴小小; 吴琦; 金叶; 刘顺; 李姣姣; 吉敬; 史大华; 沈金阳; 刘玮炜

doi:10.14148/j.issn.1672-0482.2021.0311

海洋天然产物中α-葡萄糖苷酶抑制剂研究进展

doi: 10.14148/j.issn.1672-0482.2021.0311

朱月霞^{1, 2, 3,},
邵仲柏¹,
吴小小¹,
吴琦⁴,
金叶⁵,
刘顺⁶,
李姣姣¹,
吉敬¹,
史大华¹,
沈金阳^{1, 2, 3, ,},
刘玮炜^{1, 2, 3, ,}

1.
江苏海洋大学药学院，江苏连云港 222005
2.
江苏省海洋生物资源与环境重点实验室，江苏连云港 222005
3.
江苏省海洋生物产业技术协同创新中心，江苏连云港 222005
4.
连云港市食品药品检验检测中心，江苏连云港 222000
5.
扬州市中医院药剂科，江苏扬州 225001
6.
南京医科大学康达学院，江苏连云港 222000

基金项目:

江苏高校优势学科建设工程资助项目

江苏海洋大学人才引进科研基金 KQ19059

详细信息

作者简介:
朱月霞，女，硕士研究生，E-mail：18816236673@163.com

通讯作者:
刘玮炜，女，教授，主要从事海洋药学研究，E-mail: liuweiwei323@163.com

沈金阳，男，讲师，主要从事海洋药学研究，E-mail：sjy898989@sina.com

中图分类号: R282.77
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- 文章访问数: 409
- HTML全文浏览量: 47
- PDF下载量: 472
- 被引次数: 0
出版历程
- 收稿日期: 2020-04-20
- 网络出版日期: 2021-12-21
- 刊出日期: 2021-03-10
- 发布日期: 2021-03-15

Research Progress of α-Glucosidase Inhibitors from Marine Natural Products

ZHU Yue-xia^{1, 2, 3
,},
SHAO Zhong-bai¹,
WU Xiao-xiao¹,
WU Qi⁴,
JIN Ye⁵,
LIU Shun⁶,
LI Jiao-jiao¹,
JI Jing¹,
SHI Da-hua¹,
SHEN Jin-yang^{1, 2, 3
, ,},
LIU Wei-wei^{1, 2, 3
, ,}

1.
College of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China
2.
Jiangsu Key Laboratory of Marine Biological Resources and Environment, Lianyungang, 222005, China
3.
Jiangsu Marine Biological Industry Technology Collaborative Innovation Center, Lianyungang, 222005, China
4.
Lianyungang Food and Drug Inspection and Testing Center, Lianyungang, 222000, China
5.
Pharmacy Department, Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou, 225001, China
6.
Kangda College of Nanjing Medical University, Lianyungang, 222000, China

摘要

摘要: α-葡萄糖苷酶抑制剂(α-Glucosidase inhibitors，AGIs)是一类通过减少葡萄糖在肠道的吸收而降低餐后血糖的新型抗糖尿病药物。AGIs降糖平稳、安全性高，并可降低心血管并发症的发生率。但是上市AGIs药物数量较少，且均具有一定副作用，使得开发新型AGIs具有重要意义。海洋天然产物作为药物开发的重要宝库，是寻找开发新型AGIs的重要方向。该文综述了59个来源于海洋动物、藻类和微生物的天然AGIs，对他们的化合物类型和活性进行了介绍，为从海洋天然产物中开发新型高效的AGIs提供参考。
- α-葡萄糖苷酶抑制剂 /
- 糖尿病 /
- 海洋天然产物
Abstract: The α-glucosidase inhibitors (AGIs) are a kind of new antidiabetic drugs that can slow down the absorption of glucose in the intestinal tract and reduce postprandial blood glucose. AGIs can stabilize and gradually maintain blood glucose at a certain level without inducing complications. However, the number of AGIs drugs on the market is small and all of them have certain side effects, which makes it of great significance to develop new AGIs. As an important source of drug development, the marine natural product is an important way to find new AGIs. In this paper, natural AGIs from 59 marine animals, algae and microorganisms were reviewed to provide references for the development of new safe and efficient AGIs from marine natural products.
- α-glucosidase inhibitors /
- diabetes mellitus /
- marine natural products

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图 1 海参来源的AGIs化学结构式

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图 2 海绵、海鞘来源的AGIs化学结构式

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图 3 褐藻来源的AGIs化学结构式

注：化合物20化学结构式文献未报道

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图 4 红藻来源的AGIs化学结构式

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图 5 绿藻来源的AGIs化学结构式

注：化合物39~40化学结构式文献未有报道。

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图 6 海洋微生物来源的AGIs化学结构式

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表 1 海洋动物来源的AGIs

化合物	海洋动物	化合物来源	AGIs	IC₅₀	化合物种类	参考文献
1	海参	Tichopus japonicus	甘油二棕榈油酸酯(1, 3-Dipalmitolein)	4.45 μmol·L^-1(酿酒酵母)	脂肪酸	10
2			顺式-9-十八碳烯酸(Cis-9-Octadecenoic acid)	14.87 μmol·L^-1(嗜热脂肪芽孢杆菌)		9
3			7Z-十八碳二烯酸(7Z-Octadecenoic acid)	0.005 1 g·L^-1(酿酒酵母)
4			7Z，10Z-十八碳二烯酸(7Z, 10Z-Octadecadienoic acid)	0.000 49 g·L^-1(酿酒酵母) 0.000 6 g·L^-1(嗜热脂肪芽孢杆菌)
5		Pearsonothuria graeffei	海参皂苷(Sea cucumber saponins，SCS)	0.04 g·L^-1(酿酒酵母)	萜类	11
6	海绵	Penares sp.	硫酸戊内酯A1(Penarolide sulfates A1)	0.001 2 g·L^-1(酿酒酵母)	大环内酯类	12
7			硫酸戊内酯A2(Penarolide sulfates A2)	0.001 5 g·L^-1(酿酒酵母)
8			硫代戊二酸甲酯A(Penasulfate A)	0.000 14 g·L^-1(酿酒酵母)
9~11		Penares schulzei	Schulzeines A~C	0.048~0.17 μmol·L^-1(酿酒酵母)	生物碱	13
12		Ianthella sp.	Iantheran A	0.37 μmol·L^-1(酿酒酵母)	苯并呋喃类	14
13		Lendenfeldia chondrodes	1-脱氧野尻霉素6-磷酸(1-Deoxynojirimycin-6-phosphate)	K_i 0.83 μmol·L^-1(未知)	脱氧野尻霉素衍生物	15
14			N-甲基-1-脱氧野尻霉素6-磷酸(N-Methyl-1-deoxynojirimycin-6-phosphate)	K_i 6 600 μmol·L^-1(未知)
15		Haliclona sp. 93-111	1，4-二脱氧-1，4-亚氨基-D-阿拉伯糖醇(1, 4-Dideoxy-1, 4-imino-D-arabinitol)	0.000 16 g·L^-1(酿酒酵母)	多羟基吡咯烷衍生物	16
16		Callyspongia truncata	Callyspongynic acid	0.000 25 g·L^-1(酿酒酵母)	多炔类	17
17			Corticatic acid A	0.000 16 g·L^-1(酿酒酵母)
18			Petrosynol	0.004 08 g·L^-1(酿酒酵母)
19	海鞘	Synoicum macroglossum	Tiruchanduramine	0.078 2 g·L^-1(酿酒酵母)	生物碱	18

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表 2 海洋藻类来源的AGIs

化合物	海洋藻类	化合物来源	AGIs	IC₅₀	化合物种类	参考文献
20	褐藻	Ecklonia stolonifera	褐藻E. stolonifera甲醇提取物(Methanolic extract of E. stolonifera，MEE)	0.022 g·L^-1(酿酒酵母)	多酚	19
21		Ishige okamurae	二邻羟基香豆酚(Diphlorethohydroxycarmalol，DPHC)	160 μmol·L^-1(酿酒酵母)	多酚	20
22		Ecklonia cava	二鹅掌菜酚(Dieckol)	240 μmol·L^-1(酿酒酵母)	多酚	21
23		Sargassum patens	2-(4-(3，5-二羟基苯氧基)-3，5-二羟基苯氧基)苯-1，3，5-三醇[2-(4-(3, 5-Dihydroxyphenoxy)-3, 5- dihydroxyphenoxy) benzene-1, 3, 5-triol，DDBT]	0.114 g·L^-1(鼠胰腺，麦芽糖底物) 0.025 4 g·L^-1(鼠胰腺，蔗糖底物)	多酚	22
24		Padinaboergesenii	Padinolic acid	-	脂肪酸	22
25		Ascophyllum nodosum	褐藻糖胶(Fucoidan)	0.013~0.047 g·L^-1(酿酒酵母)	多糖	24
26		Macrocystis angustifolia	4-羟基苯乙醇[4-(2-Hydroxyethyl)phenol]	0.278 23 g·L^-1(酿酒酵母)	多酚	28
27			4-二羟基苯乙醇[4-(1, 2-Dihydroxyethyl)phenol]	0.335 76 g·L^-1(酿酒酵母)
28		Ecklonia stolonifera、Eisenia bicyclis	间苯三酚(Phloroglucinol)	0.141 2 g·L^-1(酿酒酵母)	多酚	29
29			二氧萘甲醚(Dioxinodehydroeckol)	0.034 6 g·L^-1(酿酒酵母)
30			鹅掌菜酚(Eckol)	0.022 8 g·L^-1(酿酒酵母)
31	红藻	Grateloupiaelliptica	2，4，6-三溴苯酚(2, 4, 6-Tribromophenol)	60.3 μmol·L^-1(酿酒酵母) 110.4 μmol·L^-1(嗜热脂肪芽孢杆菌)	多酚	30
32			2，4-二溴苯酚(2, 4-Dibromophenol)	130.3 μmol·L^-1(酿酒酵母) 230.3 μmol·L^-1(嗜热脂肪芽孢杆菌)
33		Symphyocladia latiuscula	双(2，3，6-三溴-4，5-二羟基苄基)醚(Bis(2, 3, 6-tribromo-4, 5-dihydroxybenzyl) ether)	0.03 μmol·L^-1(酿酒酵母)	多酚	31
34		Odonthalia corymbifera	4-溴-2，3-二羟基-6-羟甲基苯基2，5- 二溴-6-羟基-3-羟甲基苯基醚(4-Bromo-2, 3-dihydroxy-6-hydroxy methylphenyl-2, 5-dibromo-6-hydroxy-	25 μmol·L^-1(酿酒酵母)	醚类	32
35			双(2，3-二溴-4，5-二羟基苄基)醚[Bis(2, 3-dibromo-4, 5-dihydroxybenzyl) ether]	0.098 μmol·L^-1(酿酒酵母)	醚类
36			2，3-二溴-4，5-二羟基苄醇(2, 3-Dibromo-4, 5-dihydroxybenzyl alcohol)	89 μmol·L^-1(酿酒酵母)
37	绿藻	Chlorella ellipsoidea	all-E-Lutein	70 μmol·L^-1(酿酒酵母)	类胡萝卜素	33
38			9Z-玉米黄质(9Z-Zeaxanthin)	53.5 μmol·L^-1(酿酒酵母)
40			ELP-3	0.36 g·L^-1(酿酒酵母)	多糖	34
40			ELP-4	0.58 g·L^-1(酿酒酵母)
41		Codium dwarkense	Dwarkenoic acid	0.003 47 g·L^-1(酿酒酵母)	甾醇	34
42			Androst-5-en-3β-ol	0.005 32 g·L^-1(酿酒酵母)
43			Ergosta-5, 25-dien-3β-ol	0.003 9 g·L^-1(酿酒酵母)
44			7-Hydroxystigmasta-4, 25-dien-3-	0.009 09 g·L^-1(酿酒酵母)
45			one-7-O-β-D-fucopyranoside	0.016 89 g·L^-1(酿酒酵母)
46			8-7-Hydroxystigmasta-4, 25-dien-3-one	0.020 12 g·L^-1(酿酒酵母)
47			Stigmasta-5, 25-dien-3β-ol	0.003 31 g·L^-1(酿酒酵母)

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表 3 海洋微生物来源的AGIs

化合物	海洋微生物	化合物来源	AGIs	IC₅₀	化合物种类	参考文献
48	真菌	Aspergillus aculeatus CRI32304 (海绵Xestospongia testudinaria)	Aspergillusol A	465 μmol·L^-1(酿酒酵母) 1 060 μmol·L^-1(嗜热脂肪芽孢杆菌)	酪氨酸代谢物	37
49		Penicillium chermesinum (ZH4-E2)	Chermesinones A	24.5 μmol·L^-1(酿酒酵母)	-联苯类	38
50		(秋茄Kandeliacandel)	6'-O-去甲基三联苯林(6'-O-Desmethylterphenyllin)	0.9 μmol·L^-1(酿酒酵母)
51			3-羟基-6'-O-去甲基三联苯林(3-Hydroxy-6'-O-desmethylterphenyllin)	4.9 μmol·L^-1(酿酒酵母)
52			3, 3''-二羟基-6'-O-去甲基三联苯林(3, 3''-Dihydroxy-6'-O-desmethylterphenyllin)	2.5 μmol·L^-1(酿酒酵母)
54		Eurotium rubrum SH-823	Eurothiocin A	17.1 μmol·L^-1(酿酒酵母)	苯并	39
54		(珊瑚Sarcophyton sp.)	Eurothiocin B	42.6 μmol·L^-1(酿酒酵母)	呋喃类
55		红树林真菌B60 (老鼠簕Acanthus ilicifolius)	硝基苯基葡萄糖苷(Nitrophenyl glucoside)	160.3 μmol·L^-1(酿酒酵母)	硝基苯糖苷	40
56		红树林真菌Xylaria sp. BL321 (老鼠簕Acanthus ilicifolius)	07H239-A	6.54 μmol·L^-1(酿酒酵母)	萜类	41-42
57	单胞菌	Streptomyces sp. OUCMDZ-3434	Wailupemycins H	19.7 μmol·L^-1(鼠胰腺)	-	43
58		(浒苔Enteromorphaprolifera)	Wailupemycins I	8.3 μmol·L^-1(鼠胰腺)
59	真菌	Aspergillus versicolor OUCMDZ-2738 (浒苔Enteromorphaprolifera)	Diorcinol J	117.3 μmol·L^-1(酿酒酵母)	-	44

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