The Proposal of the Biological Axis of "Liver-Eye" Inspired by the TCM Theory of "Liver Opens at the Eyes" and Its Modern Medical Biological Evidences
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摘要: “肝开窍于目”是中医脏腑理论的重要认知，认为“眼乃五脏六腑之精华, 上注于目而为明”，并在临床实践中不断完善形成了“肝病及眼”“眼病及肝”的中医辨证与辨病理论基础和诊疗体系。随着现代医学生物学的发展，越来越多的证据表明肝脏和眼两大脏器之间在生理、病理诸方面存在着十分复杂而密切的联系, 这些生物学联系印证了“肝开窍于目”理论。因此，“肝-眼生物轴”的提出，既得益于“肝开窍于目”中医脏腑理论的启示，具有深厚的传统中医理论基础，又是人体脏器与眼部疾病之间存在共同的通路与靶点和复杂而紧密的生物学关系的客观判断。“肝-眼生物轴”的提出和不断丰富完善，必将为提升眼科学基础研究及临床诊疗水平做出应有的贡献。Abstract: "Liver opens at the eyes" is an important cognition of the viscera and bowels theory of traditional Chinese medicine, which holds that "The eye is clear based on the visceral and bowel essence flowing upwards into the eyes". In clinical practice, it has continuously improved and formed the TCM syndrome differentiation, diagnosis, treatment system and theoretical basis of "liver disease leads to ophthalmopathy" as well as "ophthalmopathy leads to liver disease". With the development of modern medical biology, more and more evidences show that there is a very complex and close relationship between the liver and the eye in physiology and pathology. We recognize the profound philosophical thought reflected in the traditional Chinese medicine theory "Liver opens at the eyes" and it is proved that the biological relationship between the liver and the eye is close and objective. Therefore, the proposal of the biological axis of "liver-eye" not only benefits from the enlightenment of the viscera and bowel theory of traditional Chinese medicine, but also has a profound theoretical foundation of traditional Chinese medicine. It is also an objective judgment of more and more evidence that there are common pathways as well as targets and complex and close biological relationships between human organs and eye diseases. There is reason to believe that the proposal and continuous enrichment and improvement of the theory of "liver-eye" axis will make proper contributions to the improvement of basic research, clinical diagnosis and treatment of ophthalmology.
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Key words:
- liver /
- eye /
- biological axis /
- liver-eye axis /
- liver opens at the eyes /
- theoretical innovation
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