川芎嗪抗消化系统肿瘤机制的研究进展

李华; 卞尧尧; 杨丽丽; 周肸; 曾莉

川芎嗪抗消化系统肿瘤机制的研究进展

李华^1,2,
卞尧尧¹,
杨丽丽¹,
周肸¹,
曾莉¹

1.
南京中医药大学第一临床医学院，江苏南京 210023
2.
河北医科大学附属邢台市人民医院，河北邢台 054001

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出版历程
- 刊出日期: 2020-05-10

Research Progress on Anti-Tumor Effect of Ligustrazine in Digestive System Neoplasms

1.
The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China
2.
Xingtai People Hospital Affiliated to Hebei Medial University, Xingtai, 054001, China

摘要

摘要: 消化系统肿瘤严重威胁着我国居民健康，其发病率和死亡率居于我国第二位。研发高效安全的抗肿瘤药物是目前亟待解决的问题，植物类提取物的抗癌功效已逐渐成为研究热点。川芎嗪是活血药川芎的有效成分，其抗肿瘤作用日渐受到关注。从影响肿瘤细胞增殖与凋亡、侵袭与转移、逆转耐药等方面对川芎嗪的抗肿瘤作用进行了综述，为进一步探索川芎嗪在消化系统肿瘤中的抗癌机制研究和新药研发提供理论依据。
- 川芎嗪 /
- 消化系统肿瘤 /
- 增殖 /
- 转移 /
- 化疗耐药
Abstract: Digestive system neoplasms remain a major threat to residents' health in our country， with the second highest morbidity and mortality in China. Therefore， there is an urgent need for developing safe and effective anti-tumor drugs. The anti-tumor effect of plant extracts has gradually become a research focus. A growing attention has been paid to anti-cancer effects of Ligustrazine， which is the effective component of Chuanxiong. We reviewed the anti-neoplastic effect of Ligustrazine from the aspects of proliferation， apoptosis， metastasis， invasion and reversion of chemotherapy resistance in neoplasms of digestive system， providing a theoretical basis and foundation for further exploring the anti-cancer mechanisms of Ligustrazine and promoting the clinical application.
- Ligustrazine /
- digestive system neoplasms /
- proliferation /
- metastasis /
- chemotherapy resistance

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