自拟柴胡牛蒡汤对SAT患者甲状腺功能及血清炎性因子水平的影响
Effect of Bupleurum Burdock Decoction on Thyroid Function and Serum Inflammatory Factors in SAT Patients
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摘要: 探讨自拟柴胡牛蒡汤治疗亚急性甲状腺炎（SAT）肝经蕴热证患者的临床效果。方法 选取我院2016年3月至2017年5月收治的110例SAT作为研究对象，采用随机数字表法分为联合组55例（西医基础疗法+柴胡牛蒡汤）、对照组55例（西医基础治疗），对比2组患者治疗前后的甲状腺功能、血清炎性因子水平。结果 2组患者治疗后颈前疼痛、发热、甲状腺肿大、怕热多汗、心悸、震颤、烦躁易怒、口干积分均低于治疗前（P<0.01），联合组优于对照组（P<0.01）；2组患者治疗后血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）、促甲状腺激素（TSH）水平低于治疗前（P<0.05~0.01）。联合组改善优于对照组（P<0.05~0.01）。结论 西医基础疗法联合柴胡牛蒡汤治疗SAT患者较单纯的西医疗法能进一步改善患者的临床症状，调节甲状腺功能，减轻炎性反应。Abstract: OBJECTIVE To explore the clinical effect of traditional Chinese medicine Bupleurum Burdock decoction for subacute thyroiditis (SAT) patients. METHODS From March 2016 to May 2017， 110 SAT patients admitted in our hospital were selected as the research object， and they were divided into the combined group (55 cases， western medicine + Bupleurum Burdock Decoction) and the control group (55 cases， western medicine) by random number table. Thyroid function and levels of serum inflammatory factors were compared before and after treatment. RESULTS After the treatment， the anterior neck pain， fever， goiter， hyperhidrosis， palpitation， tremor， irritability， weight loss and dry mouth scores in two groups were lower than those of pre-treatment (P<0.01)， and the combined group were better than the control group(P<0.01). The levels of serum free FT3， FT4， IL-6， TNF-α， hs-CRP， TSH in two groups were lower than those of the pre-treatment (P<0.05，P<0.01). The improvements in the combined group were significantly better than that in the control group (P<0.05). CONCLUSION Comparing with the simply western medicine treatment， western medicine combined with Bupleurum Burdock Decoction can further improve the clinical symptoms of SAT patients， regulate thyroid function and reduce inflammatory reaction.
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