Abstract: OBJECTIVE To explore the biological effects of extracorporeal shock-wave lithotripsy(ESWL) on kidney damage as well as the preventive and therapeutic effects of Niaoshi No.2 Formula. METHODS 60 cases with kidney stone who received ESWL surgery were randomly divided into two groups. Patients in the control group were given the routine treatment including giving large volume of water， resisting infection， removing urinary stone based on body position and dealing with the symptoms， while those in the treatment group were given Niaoshi No.2 Formula from three days before ESWL surgery to the seventh day after the surgery. Changes of urinary NAG， gamma-GT， serum beta2-MG， NAG and CysC were detected before ESWL and 24h， 72h， and 168h after operation in the two groups. RESULTES The contents of urinary NAG， γ-GT， serum β 2-MG， NAG and CysC obviously increased 24h after surgery when compared with the situations before(P<0.01); Urinary NAG and serum NAG in the treatment group were evidently lower than those of the control group 24h and 72h after ESWL surgery(P<0.05~0.01). Ureases of both groups were able to return to normal situation within 168 hours after surgery. CONCLUSION ESWL surgery can cause damage to kidney，which is reversible within a certain time and scope. Chinese medicine Niaoshi No.2 Formula has swift and good effects on kidney damage in patients after receiving ESWL surgery.