血栓弹力图评测三七皂苷联合阿司匹林对老年冠心病患者抗栓疗效的影响
Influence of Panax Notoginseng Saponins Combined with Aspirin on Senile Coronary Heart Disease by Thromboela-stogram
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摘要: 目的 通过血栓弹力图(TEG)观察三七皂苷联合阿司匹林的抗栓疗效。方法 将51例老年冠心病患者随机分为对照组和试验组,对照组口服拜阿司匹林,试验组口服三七通舒胶囊和拜阿司匹林,观察2组对TEG和花生四烯酸诱导途径血小板抑制率(AA%)的影响。结果 2组间对照显示试验组在提高R值、K值及Angle角方面有统计学差异(P<0.05~0.01)。结论 三七皂苷联合阿司匹林在抗栓方面优于单用阿司匹林,且不增加不良反应。Abstract: OBJECTIVE To observe antithrombotic effects of panax notoginseng saponins plus aspirin via applying thromboela-stogram(TEG). METHODS 51 patients with senile coronary heart disease were randomly divided into treatment group and control group, with patients in the control group being given aspirin while whose in the treatment group being treated with Sanqi Tongshu Capsule and aspirin. TEG of both groups were observed together with platelet inhibition rate(AA%) induced by arachidonic acid. There existed a statistical significance between the two groups in improving R value, K value and alpha Angle(P<0.05~0.01). RESULTS Reducing scores on SDRS and HAMA of the treatment group before and after treatment were evidently higher than those of the control group(P<0.01). Both groups were effective in improving PSG parameters including sleeping time, sleep latency and sleep efficiency after treatment(P<0.05), but the treatment group was superior to the control group(P<0.05). The total curative rate of treatment group and control group were 84.85% and 67.74% respectively with a statistical significance between the two groups(P<0.05). CONCULSION Panax notoginseng saponins plus aspirin is superior to aspirin in anti-thrombosis, without increasing the side effects.
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Key words:
- thromboela-stogram(TEG) /
- panax notoginseng saponins /
- aspirin /
- antithrombotic effect
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[1] VEJAR M, FRAGASSO G, HACKETT D, et al. Dissociation of platelet activation and spontaneous myocardial ischemia in unstable angina[J]. Thromb Haemost, 1990, 63(2): 163-168. [2] HELGASON CM, BOLIN KM, HOFF JA, et al. Development of aspirin resistance in persons with previous ischemic stroke[J]. Stroke, 1994, 25(12): 2331-2336. [3] 陈晨,刘倩,高华.活血化瘀药药理作用研究进展[J].中国药事,2011, 25(6):603-605. [4] CHEN C, LIU Q, GAO H. Research progress on the pharmacological actions of blood-activating and stasis-resolving medicine[J]. Chin Pharmaceut Affair, 2011, 25(6): 603-605. [5] 黄鹤,马莉.血栓弹力图的应用进展[J].现代临床医学,2015, 41(3):163-165, 171. [6] HUANG H, MA L. Application progress of thromboelastogram[J]. J Mod Clin, 2015, 41(3): 163-165,171. [7] 黄骅,陈可冀.血栓形成与中药防治[J].医学综述,2010,16(9):1410-1413. [8] 〖JP2〗HUANG Y, CHEN KJ. Thrombogenesis and traditional Chinese medicine prevention[J]. Med Recapit, 2010, 16(9): 1410-1413.〖JP〗 [9] 陈鹏,胡晓立,雷伟亚,等.三七叶苷对兔血小板聚集功能的影响[J].云南大学学报(自然科学版),2005, 27(1):82-85. [10] CHEN P, HU XL, LEI WY, et al. Influence of panax notoginseng saponin on platelet aggregation function of rats[J]. J Yunnan Univ: Nat Sci Edit, 2005, 27(1): 82-85. [11] 詹合琴,李平法,杨锦南,等.三七皂苷Rg1对t-PA和PAI-1水平的影响[J].中国药理学通报,2006,22(7):869 - 872. [12] ZHEN HQ, LI PF, YANG JN, et al. Influence of panax notoginseng saponins Rg-1on t-PA and PAI-1[J]. Chin Pharmacol Bull, 2006, 22(7): 869-872. [13] 阎喜荣,吴海琴,张桂莲,等.血塞通对脑梗死患者血液流变学及纤维蛋白原的影响[J].陕西医学杂志,2008, 37(2):217-218, 233. [14] 〖JP2〗YAN XR, WU HQ, ZHANG GL, et al. Influence of Xuesaitong injection on hemorheology and fibrinogen in patients with cerebral infarction[J]. Shaanxi Med J, 2008, 37(2): 217-218,233.〖JP〗 [15] 王萍,李彗风,宋鲁卿.血塞通对2型糖尿病血液流变学相关参数的影响[J].齐鲁医学杂志,2004, 19(5):423-424, 426. [16] WANG P, LI HF, SONG LQ. Influence of Xuesaitong injection on hemorheology in patients with type 2 diabetes[J]. Med J Qilu, 2004, 19(5): 423-424,426.
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