加减清营汤治疗乙肝后肝硬化内毒素血症热毒血瘀型的临床研究
Clinical Study on Modified Qingying Decoction in Treating Endotoxemia in Cirrhosis due to Hepatitis B of Toxic Heat and Blood Stasis Syndrome
-
摘要: 目的 研究加减清营汤对乙肝后肝硬化内毒素血症患者体内的内毒素水平的影响。方法 58例确诊的乙肝后肝硬化内毒素血症热毒血瘀型患者随机分为治疗组30例,对照组28例。对照组给予还原型谷胱甘肽、苦黄注射液、甘草酸二胺氯化钠保肝治疗,治疗组在对照组治疗基础上给予加减清营汤治疗。用动态浊度法检测58例乙肝后肝硬化患者血清内毒素水平,并测定血清丙氨酸氨基转移酶(ALT)、总胆红素(TBiL)及凝血酶原时间(PT)等。结果 在临床症状积分改善方面治疗组优于对照组(P<0.01),对内毒素水平的改善,治疗组优于对照组(P<0.05)。结论 加减清营汤对乙肝后肝硬化内毒素血症疗效显著。Abstract: OBJECTIVE To study the effects of modified Qingying Decoction on endotoxin levels of patients with cirrhosis endotoxemia due to hepatitis B. METHODS 58 patients with cirrhosis endotoxemia due to hepatitis B of toxic heat and blood stasis syndrome were randomly divided into treatment group(30 cases) and control group(28 cases). Patients in the control group were treated with hepatoprotective medication therapy, including reduced glutathione injection, Kuhuang injection and diammonium glycyrrhizinate and sodium chloride injection. Based on this, patients in the treatment group were further given Qingying Decoction. The endotoxin levels in the serum of these 58 patients were tested using the dynamic turbidity method, together with serum alanine aminotransferase(ALT), total bilirubin(TBiL) and prothrombin time(PT). RESULTS The treatment group was superior to the control group in decreasing clinical symptom integral(P<0.01) and even more superior in reducing endotoxin levels(P<0.05). CONCULSION Qingying Decoction has a notable curative effect on cirrhosis endotoxemia due to hepatitis B.
-
[1] 叶任高,陆再英.内科学[M].北京:人民卫生出版社,2006:440-448. [2] YE RG, LU ZY. Internal Medicine[M]. Beijing: People's medical publishing house, 2006: 440-448. [3] MENDOZA A,KML YN,CHERNOFF A. Hypoglycemia in hospitalized adult patients without diabetes[J].Endoerpract,2005,11:91-96. [4] 中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:147,150-151. [5] Chinese Traditional Medicine New Medicine Clinical Research Guiding Principles(for Trial Implementation)[M]. Beijing: The medicine science and technology press of China, 2002: 147, 150-151. [6] 张育轩,危北海.肝硬化临床诊断、中医辨证和疗效评定标准[J].中国中西医结合杂志,1994,14(4):237-238. [7] ZHANG YX, WEI BH. Clinical diagnosis, TCM syndrome differentiation and curative effect evaluation criteria for liver cirrhosis[J]. Chin J Integr Tradit West Med, 1994, 14(4): 237-238. [8] 南京中医药大学温病教研室.温病条辨[M].北京:人民卫生出版社,2005:37. [9] Warm Disease Teaching and Research Section of Nanjing University of Chinese Medicine. Systematic Differentiation of Warm Diseases[M]. Beijing: People's medical publishing house, 2005:37. [10] 黄帝内经素问[M].北京:人民卫生出版社,2005:178. [11] Annotations on the Yellow Emperor's Inner Classic[M]. Beijing: People's medical publishing house, 2005:178. [12] 徐向东,赵珠祥,赵海霞.清营汤对内毒素致热家兔的作用及其机制[J].中国实验方剂学杂志,2012,18(24):220-223. [13] XU XD, ZHAO ZX, ZHAO HX. The effects and mechanism of the Qingying Decoction on endotoxin induced fever in rabbits[J]. Chin J Exp Med Formul, 2012, 18(24): 220-223. [14] 陈静,叶柏.大黄灌肠治疗肝性脑病30例[J].南京中医药大学学报,2004,20(3):181. [15] CHEN J, YE B. 30 cases of hepatic encephalopathy treated with rhubarb enema[J]. J Nanjing Univ Tradit Chin Med, 2004, 20(3):181. [16] 孙耀光.中药抗内毒素的作用及其机制[J].现代中医药,2004,23(6):40-42. [17] SUN YG. Anti-endotoxin function of traditional Chinese medicine and its action mechanism[J]. Mod Tradit Chin Med, 2004, 23(6):40-42. [18] 张霞,吴迪,王家泰,等.穿心莲破坏内毒素作用的体外实验研究[J].中国中西医结合急救杂志,2000,7(4):212-214. [19] ZHANG X, WU D, WANG JT, et al. An in vitro experiment on destruction of endotoxin of Andrographis paniculata[J]. Chin J Integr Tradit Chin West Med Intensive Crit Care, 2000, 7(4) : 212-214.
点击查看大图
计量
- 文章访问数: 789
- HTML全文浏览量: 2
- PDF下载量: 632
- 被引次数: 0