醒脑静注射液对急性脑出血患者血清hs-CRP、IL-6的影响

朱春然; 徐重白

醒脑静注射液对急性脑出血患者血清hs-CRP、IL-6的影响

朱春然¹,
徐重白²

1.
南京中医药大学第一临床医学院，江苏南京 210023
2.
南京中医药大学附属江苏省中西医结合医院，江苏南京 210028

计量
- 文章访问数: 928
- HTML全文浏览量: 2
- PDF下载量: 660
- 被引次数: 0
出版历程
- 收稿日期: 2012-12-20
- 修回日期: 2013-01-21
- 刊出日期: 2013-05-10

Effects of Xingnaojing Injection on hs-CRP and IL-6 in the Serum of Patients with Acute Cerebral Hemorrhage

ZHUChun-ran¹,
XUChong-bai²

1.
The First Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, China
2.
Jiangsu Provincial Hospital of Combined Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210028, China

摘要

摘要: 目的探讨血清超敏C反应蛋白（hs-CRP）、白介素6(IL-6)与脑出血患者的关系，观察醒脑静注射液对hs-CRP、IL-6的影响，阐明醒脑静注射液治疗脑出血的可能机理。方法将90例急性脑出血患者随机分为试验组和对照组，对照组给予降颅压、止血药等常规治疗，试验组在常规治疗基础上加用醒脑静注射液静滴，于治疗前，治疗第2、3、8、14 d，取试验组45例、对照组45例脑出血患者静脉血，采用免疫比浊法检测hs-CRP，电化学发光法检测IL-6。结果 hs-CRP、IL-6呈缓慢下降曲线，醒脑静注射液干预治疗组下降更明显（P<0.05~0.01）。hs-CRP、IL-6值第3天组间比较P<0.05，组间具有显著性差异。结论醒脑静注射液对急性脑出血有明显的治疗作用，可能是一种有效的CRP、IL-6抑制剂和神经保护剂。
- 脑出血 /
- 血清C反应蛋白 /
- 白细胞介素6 /
- 醒脑静注射液
Abstract: OBJECTIVE To explore the relation between hs-CRP， IL-6 in the Serum and acute cerebral hemorrhage， observe the influence of Xingnaojing Injection on hs-CRP and IL-6， expound the possible mechanism of Xingnaojing Injection for treating cerebral hemorrhage. METHODS 90 cases with acute cerebral hemorrhage were randomized into experimental group and control group. The control group were given regular treatment with ICP-lowering and styptic drugs. Experimental group were given Xingnaojing Injection on the basis of regular treatment. After 14 days' treatment， venous blood of 45 patients in experimental group and 45 patients in control group was drawn. Immunoturbidimetry was applied for detecting hs-CRP and electrochemiluminescence was applied for detecting IL-6. RESULTS The change of hs-CRP and IL-6 presented decline curve. The decline in the treatment goup is much more obvious (P<0.05~0.01). There was significant difference when the value of hs-CRP and IL-6 on the 3ir day (P<0.05). CONCLUSION Xingnaojing Injection has notable therapeutic effects on acute cerebral hemorrhage and it is probably an effective inhibitor and nervous protective agent of CRP and IL-6.
- cerebral hemorrhage /
- hs-CRP /
- IL-6 /
- Xingnaojing Injection

HTML全文

参考文献(18)

[1]	王忠诚．神经外科学[M].武汉：湖北科学技术出版社，2008：864.
[2]	Wang ZC. Neurosurgery[M]. Wuhan: Hubei science & technology press， 2008: 864.
[3]	中华神经科学会.脑血管疾病分类诊断要点[J].中华神经科杂志，1996，29（6）：379.
[4]	China's neuroscience association. Classified diagnostic essentials for cerebrovascular diseases[J]. Chin J Neurol，1996，29(6): 379
[5]	国家中医药管理局脑病急症协作组.中风病诊断与疗效评定标准[J].北京中医药大学学报，1996， 19（1）：55-56.
[6]	Cerebral acute diseases association of state administration of traditional Chinese medicine. Diagnosis of stroke and standards for effect evaluation[J]. J Beijing Univ Tradit Chin Med，1996，19 (1):55-56.
[7]	脑卒中患者临床神经功能缺损程度评分标准[J].中华神经科杂志，1996，29(6):381.
[8]	Clinical standard on the patients with cerebral apoplexy nerve function defection[J]. Chin J Neurol， 1996，29(6):381.
[9]	徐耕，金国栋，傅国胜，等.急性冠脉综合征患者C-反应蛋白及其1 059G/C基因多态性研究[J].中华急救医学杂志，2003，12（5）：223-226.
[10]	Xu G， Jin GD， Fu GS， et al. Research on C-Reactive Protein and its 1 059G/C gene polymorphism of patients with acute coronary syndrome[J]. Chin J Emerg Med， 2003，12(5): 223-226.
[11]	Pasceri V， Willerson JT， Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells[J]. Circulation， 2000， 102(18): 2165-2168.
[12]	李丽.急性脑出血患者血清TNF-a，IL-6，NO的动态测定及临床意义[J].中国医师杂志，2003， 5（12）：1711-1712.
[13]	Li L. Dynamic detection of TNF-a，IL-6，NO in the serum of patients with acute cerebral hemorrhage and its clinical significance[J]. J Chin Physic，2003，5(12): 1711-1712.
[14]	spittler A， Razenberger M， Kupper H， et al. Relationship between interleukin-6 plasma concentration in patients with sepsis，monocyte phenotype，monocyte phagocytic properties，and cytokine production[J]. Clin Infect Dis， 2000， 31(6): 1338-1420.
[15]	张小红，欧阳方，张淑琴.醒脑静辅助治疗脑出血的临床观察[J].湖北中医杂志，2011，33（4）：15-16.
[16]	Zhang XG， Ou YF， Zhang SQ.Clinical observation of Xingnaojing as adjuvant treatment for cerebral hemorrhage [J].Hubei J Tradit Chin Med，2011，33(4): 15-16.
[17]	李保平，马金叶.醒脑静注射液对脑出血后脑水肿的影响和疗效观察[J].河南大学学报:医学版，2006， 25（1）：43-44.
[18]	Li BP， Ma JY. Effects of Xingnaojing Injecta on encephaledema after cerebral hemorrhage and clinical observation[J]. J Henan Univ: Med Sci，2006，25(1): 43-44.