麝香保心丸联合热敏灸治疗冠心病心绞痛临床研究
Clinical Study on Treatment of Coronary Heart Disease with Angina Pectoris by Shexiang Baoxin Pill Combined with Thermal Moxibustion
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摘要: 目的 观察麝香保心丸联合热敏灸治疗冠心病心绞痛的临床疗效。方法 选择我院收治的冠心病心绞痛住院患者124例,随机分为2组,各62例,对照组给予口服抗血小板药物、硝酸酯剂、β-受体阻滞剂、他汀类,积极控制血压、血糖等治疗,治疗组在对照组治疗基础上给予麝香保心丸联合热敏灸治疗,比较2组临床疗效及治疗前后血清炎症因子水平变化如C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α),血脂水平变化如甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、QT间期离散度(QTd)以及心脏缺血相关事件等。结果 2组患者治疗后血清炎症因子(CRP、IL-6、TNF-α)水平、血脂(TG、TC、LDL-C)水平、QT离散度均得到改善(P<0.05~0.01),治疗组改善程度均明显优于对照组(P<0.05~0.01),治疗组发生心脏缺血相关事件较对照组明显减少,差异具有统计学意义(P<0.01)。结论 麝香保心丸联合热敏灸综合治疗,能有效改善冠心病心绞痛患者临床症状和生活质量,明显降低心脏缺血相关事件的发生。Abstract: OBJECTIVE To observe the clinical effect of Shexiang Baoxin pill combined with thermal moxibustion treating coronary heart disease angina pectoris.METHODS 124 inpatients with coronary heart disease angina pectoris in our hospital were randomly divided into two groups, 62 each. Besides positive control of blood pressure and blood glucose, the control group was given standard western medicine treatment: oral antiplatelet drugs, nitrates, β-blockers and statins. The treatment group was treated with Shexiang Baoxin pill combined with thermal moxibustion on the basis of the control group. The clinical efficacy, the changes of serum levels of inflammatory factors, the changes of blood lipid levels, QT interval dispersion (QTd), cardiac ischemia-related events and other factors in the two groups before and after the treatment were compared. As for the changes of serum levels of inflammatory factors, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) were assessed while for the changes of blood lipid levels, triglyceride (TG), cholesterol (TC), low density lipoprotein (LDL-C) were observed. RESULTS After treatment, the levels of serum inflammatory factors (CRP, IL6, TNF-α), blood lipid levels (TG, TC, LDL-C) and QT dispersion were improved in both groups (P<0.05,P<0.01). The improvement of the treatment group was significantly better than that of the control group (P<0.05,P<0.01). The occurrence of ischemia-related events in the treatment group was significantly reduced compared with that in the control group (P<0.01). CONCLUSION Shexiang Baoxin pill combined with thermal moxibustion can effectively improve the clinical symptoms and life quality of patients with coronary heart disease angina pectoris, and significantly reduce the occurrence of ischemia-related events.
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