中医药防治肾纤维化的研究现状及实践
Research Progress of Chinese Medicine in the Treatment of Renal Fibrosis
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摘要: 肾纤维化是各种慢性肾脏病进展至终末期肾病的病理基础,可危及生命。其发病机制较为复杂,由多种细胞因子和信号通路共同参与。目前尚无有效治疗药物。近年来基于肾纤维化的中医理论及其分子机制,通过随机多中心临床研究以及体内外基础研究,证实多种中药及其有效成分有延缓肾纤维化的疗效,并明确了作用靶点。继续寻找有效的延缓肾纤维化的中药,证实其疗效,明确作用机制尤为重要。Abstract: Renal fibrosis is the pathological basis of the progression of various chronic renal diseases to end-stage renal disease, which is life-threatening. Its pathogenesis is complex and is involved in a variety of cytokines and signaling pathways, and there is no effective therapeutic drug until now. In recent years, on the basis of TCM theory of renal fibrosis and its molecular mechanism, through randomized multicenter clinical study and basic research in vitro and in vivo, our hospital confirmed that a variety of Chinese herbs and their effective components have the effect of delaying renal fibrosis, and we have identified their action target. In a word, we should continue to find effective Chinese medicine that can postpone renal fibrosis, to confirm their curative effect, especially to clear their action mechanism.
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