天然中药单体及衍生物调控miRNAs抗非小细胞肺癌的作用机制研究进展

姜泽群; 吴勉华; 杨烨

天然中药单体及衍生物调控miRNAs抗非小细胞肺癌的作用机制研究进展

1.
南京中医药大学医学与生命科学学院，江苏南京 210023
2.
南京中医药大学第一临床医学院，江苏南京 210023
3.
南京中医药大学整合医学院，江苏南京 210023

计量
- 文章访问数: 2743
- HTML全文浏览量: 26
- PDF下载量: 1801
- 被引次数: 0
出版历程
- 收稿日期: 2017-12-23
- 刊出日期: 2018-09-10

Research Progress on Anti-Non-Small Cell Lung Cancer Mechanisms of Natural Chinese Medicine Monomer and Its Derivatives by MiRNAs Regulation

1.
School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, China
2.
The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, China
3.
Integrated Medical School, Nanjing University of Chinese Medicine, Nanjing, 210023, China

摘要

摘要: 非小细胞肺癌（NSCLC）是目前对人类健康威胁最大的恶性肿瘤之一，亟待探索新型的抗癌疗法。随着对天然中药抗癌活性研究的不断深入，天然中药单体及衍生物在调控NSCLC细胞生长、增殖、侵袭、迁移、药敏性等方面的miRNAs研究越来越受到关注。就天然中药单体及衍生物调控miRNAs抑制NSCLC的最新进展做一综述，旨在为NSCLC药物的研发提供新的思路和参考。
- 中药单体 /
- 非小细胞肺癌 /
- miRNA
Abstract: Non-small cell lung cancer (NSCLC) is one of the most serious threats to human beings. There is an urgent need to develop new anti-cancer therapies. With the deepening of the research on the anticancer activity of natural Chinese medicine， miRNAs research on the growth， proliferation， invasion， migration and drug sensitivity of NSCLC cells by regulation of natural Chinese medicine monomer and its derivatives has been paid more and more attention. This paper gives an overview of the latest research progress on the anti-NSCLC effects of natural medicine components and derivatives via miRNAs regulation， which aims to provide new ideas and references for the development of NSCLC drugs.
- natural Chinese medicine monomer /
- non-small cell lung cancer /
- miRNA

HTML全文

参考文献(45)

[1]	CHEN WQ， ZHENG RS， BAADE PD， et al. Cancer statistics in China， 2015[J]. CA Cancer J Clin， 2016， 66(2): 115-132.
[2]	SIEGEL RL， MILLER KD， JEMAL A. Cancer statistics， 2017[J]. CA Cancer Clin， 2017， 67: 7-30.
[3]	ANDERWS J， YEH P， PAO W， et al. Molecular predictors of response to chemotherapy in non-small cell lung cancer[J]. Cancer J， 2011， 17(2): 104-113．
[4]	ALIPOOR SD， ADCOCK IM， GARSSEN J， et al. The roles of miRNAs as potential biomarkers in lung diseases[J]. Eur J Pharmacol， 2016， 791: 395-404.
[5]	MARKOU A， TSAROUCHA EG， KAKLAMANIS L， et al. Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR[J]. Clin Chem， 2008， 54(10): 1696-1704.
[6]	YANG J， LIU H， WANG H， et al. Down-regulation of microRNA-181b is a potential prognostic marker of non-small cell lung cancer[J]. Pathol Res Pract， 2013， 209(8): 490-494.
[7]	SUN C， LI S， YANG C， et al. MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6[J]. Biochem Biophys Res Commun， 2016， 471(1): 82-88.
[8]	SHANG Y， ZANG A， LI J， et al. MicroRNA-383 is a tumor suppressor and potential prognostic biomarker in human non-small cell lung cancer[J]. Biomed Pharmacother， 2016， 83: 1175-1181.
[9]	BAE S， LEE EM， CHA HJ， et al. Resveratrol alters microRNA expression profilesin A549 human non-small cell lung cancer cells[J]. Mol Cells， 2011， 32(3):243-249
[10]	韩志远，张慧，杨巧媛. 白藜芦醇抑制H460肺癌细胞的增殖作用研究[J]. 中国热带医学， 2014， 14(1): 12-15.
[11]	TANG XL， YANG XY， JUNG HJ， et al. Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade[J]. Biol Pharm Bull， 2009， 32(8): 1399-1405.
[12]	HSU YL， KUO PL， LIN LT， et al. Asiatic acid， a triterpene， induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells[J]. J Pharmacol Exp Ther， 2005， 313(1): 333-344.
[13]	KIM KB， KIM K， BAE S， et al. MicroRNA-1290 promotes asiatic acid?偉cinduced apoptosis by decreasing BCL2 protein level in A549 non-small cell lung carcinoma cells[J]. Oncol Rep， 2014， 32(3): 1029-1036.
[14]	QIAN G， WANG Z， ZHAO J， et al. Synthesis and anti-cancer cell activity of pseudo-ginsenoside Rh2[J]. Steroids， 2014， 92: 1-6．
[15]	张彩华，李骢，李华军，等. 人参皂苷Rh2对肺癌A549细胞miR-16和Bcl-2表达与生长的影响研究[J]. 中国微生态学杂志， 2015， 27(9): 1027-1030.
[16]	YANG TQ， LU XJ， WU TF， et al. MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP-9 signaling pathway[J]. Cancer Sci， 2014， 105(3): 265-271．
[17]	WU J， ZHAO S， TANG Q， et al. Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells[J]. J Exp Clin Cancer Res， 2015， 34(1):99.
[18]	崔兵兵，程丽芳，侯立静，等. 熊果酸抑制人肝癌SMMC-7721 细胞生长及凋亡的实验研究[J]. 中国实验方剂学杂志， 2013， 19(18): 181-184.
[19]	张慧锋，郭淑英，申蕾，等. 熊果酸诱导SKOV3 细胞凋亡与线粒体凋亡通路[J]. 中药药理与临床， 2015， 31(2): 140-142.
[20]	〖JP3〗LEWINSKA A， ADAMCZYK-GROCHALA J， KWASNIEWICZ E， et al.〖JP〗Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells[J]. Apoptosis， 2017， 22(6): 800-815.
[21]	梁敏，陈欣. 熊果酸通过调节miRNA-133a抑制肺癌A549细胞的迁移和侵袭[J]. 中国病理生理杂志， 2016， 32(12): 2239-2244.
[22]	纪春梅，甄永占，骆广玲，等. 赖氨大黄酸通过升高miRNA-451抑制肺癌 A549细胞迁移[J]. 第三军医大学学报， 2014， 36(3): 248-252.
[23]	RUAN H， LIANG X， ZHAO W， et al. The effects of microRNA-183 promots cell proliferation and invasion by targeting MMP-9 in endometrial cancer[J]. Biomed Pharmacother， 2017， 89: 812-818.
[24]	刘昌杰. 虫草素对体外培养肺癌细胞株A549恶性生物学行为的调节及其与相关miRNA表达的关系[J]. 海南医学院学报， 2015， 21(12): 1597-1600.
[25]	LI C， CHEN J， LU B， et al. Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells[J]. PLoS ONE， 2014， 9(7): e101526.
[26]	LIU B， ZHANG BM. Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells[J]. Biochim Biophys Acta， 2009， 1790(8): 840-844.
[27]	YANG Y， XU HL， ZHANG ZT， et al. Characterization， molecular cloning， and in silico analysis of a novel mannose-binding lectin from Polygonatum odoratum (Mill.) with anti-HSV-II and apoptosis-inducing activities[J]. Phytomedicine， 2011， 18(8): 748-755.
[28]	LEI W， TAO L， YAN X， et al. Polygonatum odoratum， lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a-3p in human lung adenocarcinoma A549 cells[J]. Int J Biol Macromol， 2016， 85: 217-226.
[29]	ZHANG W， BAI W， ZHANG W. MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small cell lung cancer A549 cells[J]. Clin Transl Oncol， 2014， 16(8): 708-713.
[30]	KUMAR VB， YUAN TC， LIOU JW， et al. Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles[J]. Mut Res， 2011， 707(1): 42-52.
[31]	RANGWALA R， CHANG YC， HU J， et al. Combined MTOR and autophagy inhibition[J]. Autophagy， 2014， 10(8): 1391-1402.
[32]	胡丽丽，尹燕军，钟文娟，等. miR-200c增强肺癌A549细胞对紫杉醇及吉非替尼的敏感度及相关机制[J]. 肿瘤防治研究， 2015， 42(8): 760-764.
[33]	PRISLEI S， MARTINELLI E， MARIANI M， et al. MiR-200c and HuR in ovarian cancer[J]. BMC Cancer， 2013， 13(1): 1-14.
[34]	DU L， BORKOWSKI R， ZHAO Z， et al. A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel[J]. RNA Biol， 2013， 10(11): 1700-1713.
[35]	RAMANATHAN R， SIVANESAN K. Evaluation of ameliorative ability of Silibinin against zidovudine and isoniazid-induced hepatotoxicity and hyperlipidaemia in rats: Role of Silibinin in Phase I and II drug metabolism[J]. Chem Biol Interact， 2017， 273: 142-153.
[36]	CUI CX， DENG JN， LI Y， et al. Silibinin capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidation[J]. J Ethnopharmacol， 2017， 208: 24-35.
[37]	BYUN HJ， DARVIN P， KANG DY， et al. Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells[J]. Oncol Rep， 2017， 37(6): 3270-3278
[38]	CUFI S， BONAVIA R， VAZQUEZMARTIN A， et al. Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo<\i>[J]. Sci Rep， 2013， 3(8): 2459-2468.
[39]	ZHOU DH， WANG X， FENG Q. EGCG enhances the efficacy of cisplatin by downregulating hsa-miR-98-5p in NSCLC A549 cells[J]. Nutr Cancer， 2014， 66(4): 636-644.
[40]	REN Z， TONG H， CHEN L， et al. MiR-211 and miR-429 are involved in emodin's anti-proliferative effects on lung cancer[J]. Int J Clin Med， 2016， 9: 2085-2093.
[41]	PATANI N， JIANG W， MANSEL R， et al. The mRNA expression of SATB1 and SATB2 in human breast cancer[J]. Cancer Cell Int， 2009， 9: 18-27.
[42]	WANG S， ZHOU J， WANG XY， et al. Down-regulated expression of SATB2 is associated with metastasis and poor prognosis in colorectal cancer[J]. J Pathol， 2009， 219: 114-122.
[43]	WEI J， SHI Y， ZHENG L， et al. MiR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2[J]. J Cell Biol， 2012， 197: 509-521.
[44]	王妍，付琳，王恩华. CRKL在人非小细胞肺癌中的表达及意义[J]. 解剖科学进展， 2013， 19(3): 225-228.
[45]	LI YJ， YU CH， LI JB， et al. Andrographolide antagonizes cigarette smoke extract-induced inflammatory response and oxidative stress in human alveolar epithelial A549 cells through induction of microRNA-218[J]. Exp Lung Res， 2013， 39(10): 463-471.