缺血修饰性白蛋白与2型糖尿病血瘀证的相关分析

尚文斌; 王金玲; 于希忠; 高燕

缺血修饰性白蛋白与2型糖尿病血瘀证的相关分析

南京中医药大学第一临床医学院，江苏南京 210023

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出版历程
- 收稿日期: 2013-03-14
- 修回日期: 2013-04-10
- 刊出日期: 2013-07-10

Analysis on Relation Between Serum Ischemia Modified Albumin and Blood Stasis Syndrome of Type 2 Diabetes

摘要

摘要: 目的探讨血清缺血性修饰蛋白(IMA)水平与2型糖尿病血瘀证的相关性，为研究糖尿病中医证型的客观化提供一定的参考依据。方法收集2型糖尿病患者79例，依据中医学辨证分型分为：血瘀证组34例，非血瘀证组45例。检测患者血清IMA水平，记录并分析患者IMA水平与年龄、体质量指数（BMI）、糖脂代谢指标[空腹血糖（FBG）、糖化血红蛋白（HbAlc）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）]及血压（SBP、DBP）的相关情况。结果与非血瘀证组相比，血瘀证组FBG、HbA1c及IMA水平较高，且达到统计学意义（P＜0.05）；Pearson相关分析显示全部病例血清IMA与HbA1c呈正相关关系（P<0.05），偏相关分析显示排除BMI、年龄、血TC、TG、HDL-C、LDL-C、SBP、DBP的影响后，血清IMA与FBG、HbA1c未见显著性相关关系（P>0.05）。结论血清IMA水平反映了2型糖尿病瘀血证的征象，可能成为独立于血糖水平以外的血瘀证的客观指标。
- 糖尿病 /
- 缺血修饰性白蛋白 /
- 血瘀证
Abstract: OBJECTIVE To investigate the relation between serum ischemia modified albumin (IMA) and Blood stasis syndrome of Type 2 diabetes in order to provide referential evidences for standardization of treating diabetes based on traditional Chinese medicine (TCM) syndrome differentiation. METHODS 79 subjects with Type 2 diabetes were gathered and divided into Blood stasis syndrome group(34 cases) and non-Blood stasis syndrome group(45 cases) according to the diagnostic theory of traditional Chinese medicine. Serum IMA of each patient was detected， and its relation correspondingly with age， BMI， glucolipid metabolism index (FBG， HbAlc， TC， TG， LDL-C， HDL-C) and blood pressure (SBP， DBP) were recorded and analyzed. RESULTS Compared with non-Blood stasis syndrome group， IMA， FPG and HbA1c were significantly higher in Blood stasis syndrome group with a stastistic significance. Pearse corelation analysis showed that all the patients' serum IMA was positively correlated with HbA1c (P<0.05). However， partial correlation analysis showed that excluding the influence of age， BMI， blood TC， TG， HDL-C， LDL-C， SBP， DBP， there was no significant correlation between serum IMA and FBG， as well as serum IMA and HbA1c (P>0.05). CONCLUSION The serum IMA level reflects the features of blood stasis syndrome of type 2 diabetes， and may be independent of glucose levels outside the blood stasis syndrome.Serum IMA is another objective marker of Blood stasis syndrome of Type 2 diabetes except glucose levels.
- diabetes /
- ischemia modified albumin /
- blood stasis syndrome

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参考文献(9)

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