姜香安胃软胶囊质量标准研究

吴趋凡; 高明; 李耿

姜香安胃软胶囊质量标准研究

广州中医药大学中药学院，广东广州 510405

计量
- 文章访问数: 763
- HTML全文浏览量: 73
- PDF下载量: 656
- 被引次数: 0
出版历程
- 收稿日期: 2012-10-19
- 修回日期: 2012-12-01
- 刊出日期: 2013-01-10

Quality Standard Study on Jiangxiang Anwei Soft Capsules

摘要

摘要: 目的建立中药复方制剂姜香安胃软胶囊（高良姜、木香、干姜）的质量标准控制方法。方法采用薄层色谱法对本品中的高良姜、干姜、木香进行定性鉴别；用高效液相色谱法测定制剂中木香烃内酯、去氢木香烃内酯的含量。结果木香烃内酯在0.103～1.030 μg(r=0.999 5，n=7）范围内线性良好，平均回收率为97.27%，RSD=1.10%；去氢木香烃内酯在0.126～1.260μg(r=0.999 6，n=7）范围内线性良好，平均回收率为97.90%，RSD=1.05%。结论该方法准确、可靠，可用于控制姜香安胃软胶囊的质量。
- 姜香安胃软胶囊 /
- 质量标准 /
- 高效液相色谱 /
- 木香烃内酯
Abstract: OBJECTIVE To establish the controlling methods for quality standard of jiangxiang Anwei Soft Capsules(Rhizoma Alpiniae Officinari， Rhizoma Zingiberis， Radix Aucklandiae).METHODS Rhizoma Alpiniae Officinari， Rhizoma Zingiberis， Radix Aucklandiae were identified by thin-layer chromatography(TLC). The contents of costunolide and dehydro-costunolide were determined by High Performance Liquid Chromatography (HPLC) together. RESULTS Consimilitude showed a good linear relationship at the range of 0.103～1.030 μg( r=0.999 5，n=7），the average recovery was 97.27%， RSD was 1.10%;Dehydro-costunolide showed a good linear relationship at the range of 0.126～1.260 μg(r=0.999 6，n=7）， the average recovery was 97.90%，and RSD was 1.05%.CONCLUSION This method is accurate， reliable， and can be used for quality control of Jiangxiang Anwei Soft Capsule.
- Jiangxiang Anwei Soft Capsule /
- quality standard /
- HPLC /
- costunolide

HTML全文

参考文献(6)

[1]	彭钧，操电群，李小月．高良姜超临界萃取物对应激性溃疡模型大鼠溃疡形成和胃液分泌及生长抑素水平的影响[J]．安徽医药，2008， 12（10）：895-897．
[2]	Peng J， Cao DQ， Li X.Y. Effect of extraction from rhizoma alpiniae officinarum by CO2 SFE on ulcer index and gastric secretion and somatostatin about stress ulcer[J]. Anhui Med Pharm， 2008， 12 (10): 895-897.
[3]	江涛，唐春萍，冯毅凡，等．高良姜总黄酮对实验性胃黏膜损伤的保护作用及其机制[J]．中草药，2009， 40（7）：1117-1119．
[4]	Jiang T， Tang CP， Feng YF， et al. Protective effect and mechanism of galangal general flavone to experimental gastric mucosal injury[J]. Chin Tradit Herb Drugs， 2009， 40 (7): 1117-1119.
[5]	何洋，乔明福，何琳，等．HPLC法同时测定利胆排石片中木香烃内酯和去氢木香内酯的含量[J]．沈阳药科大学学报，2009， 26（7）：543-546．
[6]	He Y， Qiao MF， He L， et al. Simultaneous determination of costunolide and dehydrocostuslactone in lidanpaishi tablets by HPLC[J]. J Shenyang Pharm Univ， 2009， 26 (7): 543-546.