Abstract: OBJECTIVE To observe the clinical effect of modified Wuling Powder in the treatment of central serous chorioretinopathy(CSC) according to syndrome differentiation. METHODS Sixty patients with CSC were randomly divided into the treatment group and the control group， 30 cases in each group. The treatment group was intervened by orally taking modified Wuling Powder， and the control group was treated with orally taking vitamin B1 tablets and vitamin C tablets， with one course lasting for one month. Clinical effects were observed after 3 courses of treatment. RESULTS The total effective rate in the treatment group was 96.7%， and 73. 3% in the control group. The curative effect was better in the treatment group than that of the control group(P<0.05). Vision， FFA fluorescence leakage area and edema degree were compared before and after treatment to be significantly different in two groups(P<0.01). The treatment group was better than the control group(P<0.05). CONCLUSION Modified Wuling Powder has good curative effects in the treatment of CSC.