养血软坚片的制备工艺研究

Study on Preparation Technology of Yangxue Ruanjian Tablet

1.
Department of Pharmacy, Henan Provincial Institute of Food and Drug Control, Zhengzhou, 450003, China
2.
Department of Science Technology, Shanghai University of Chinese Medicine, Shanghai, 201203, China

摘要: 目的研究养血软坚片的处方组成和制备工艺。方法以流化喷雾制粒难度、休止角、片面光洁度、硬度、崩解时限为指标，单因素法优选片剂处方。结果按照稠浸膏-生药粉-微晶纤维素-羧甲基淀粉钠-糊精(300∶50∶6∶3∶1)的比例混合，流化制粒，压片、包薄膜衣。结论养血软坚片处方合理，工艺简便易行，可达到生产要求。
- 养血软件片 /
- 流化喷雾制粒 /
- 制备工艺 /
- 薄膜包衣 /
- 含量测定
Abstract: OBJECTIVE To study the formation and preparation technology of Yangxue Ruanjian Tablet. METHODS The single-factor method was taken to optimize the pharmaceutical formulations and the content was selected by granulating difficulty， angle of repose， degree of surface smoothness， hardness and disintegration. RESULTS Fluidized-bed granulating， tabletting and coating the mixture of raw powder， microcrystalline cellulose(MCC)， Sodium carboxymethyl starch and dextrin were made according to the proportion of 300: 50: 6: 3: 1. CONCLUSION Yangxue Ruanjian Tablet is reasonable and the process is simple and feasible， which conforms to the requirements for production.
- Yangxue Ruanjian Tablet /
- fluidization spray granulating /
- process technology /
- film coating /
- content determination

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