补心软脉颗粒对大鼠急性心肌缺血损伤的保护作用

赵林钢; 钱玉良; 许立; 严冬

补心软脉颗粒对大鼠急性心肌缺血损伤的保护作用

赵林钢^1,2,
钱玉良¹,
许立²,
严冬^1,

1.
南京中医药大学附属医院，江苏南京 210029
2.
南京中医药大学药学院，江苏南京 210023

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出版历程
- 收稿日期: 2014-05-15
- 修回日期: 2014-08-15
- 刊出日期: 2014-09-10

The Protective Effects of Buxin Ruanmai Granules on Rats with Acute Myocardial Ischemia

1.
The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China
2.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China

摘要

摘要: 目的观察补心软脉颗粒对异丙肾上腺素（ISO）大鼠心肌缺血损伤的保护作用。方法采用四肢根部和背部皮下多点注射ISO制备大鼠急性心肌缺血模型，观察补心软脉颗粒对心电图ST段位移的影响，并测定血清LDH、CK活性及心肌病理学形态。结果补心软脉颗粒对ISO所致心肌缺血大鼠心电图ST段，心肌损伤酶学指标（LDH、CK）和组织病理学均有明显的改善作用。结论补心软脉颗粒通过增强机体对心肌缺血的耐受力，稳定细胞膜，减少心肌坏死范围起到保护心肌的作用。
- 补心软脉颗粒 /
- 大鼠 /
- 急性心肌缺血损伤
Abstract: OBJECTIVE To explore the protective effects of Buxin Ruanmai Granules (BXRMG) on rats with myocardial ischemia caused by isoprenaline (ISO). METHODS The SD rat model of acute myocardial ischemia was developed by injecting isoproterenol hydrochloride (ISO) into subcutaneous tissue on the back and limbs. The effects of BXRMG on the displacements of ST region were observed at 1， 2， 3， 5， 10， 15， 20， and 30 mins after injection. Orbital blood was collected 30 minutes after modeling. Then， serum was separated and LDH and CK activities were determined and myocardial pathological morphology was observed. RESULTS The effects of BXRMG on ST region in myocardial ischemia induced by ISO indicated that LDH and CK level were improved significantly and histopathology was also improved. CONCLUSION Buxin Ruanmai Granules may protect the heart through strengthening the body's tolerance to ischemia， stabilizing the membrane and reducing the attacked areas from myocardial necrosis.
- Buxin Ruanmai Granules /
- rat /
- myocardial ischemia

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参考文献(11)

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