慢性鼻炎中医证型与鼻黏膜p38MAPK表达相关性初步研究

基金项目: 江苏省中医药管理局资助课题（H05048）

Correlation betweenTransformation of Syndromes of Chronic Rhinitis and Expression of Nose Mucous Membranep38MAPK

1 Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210046, China ;2 Higher Technological Academy of Traditional Chinese Medicine, Wuhu, Anhui , 241000, China

摘要: 目的探讨慢性鼻炎中医分型与鼻黏膜p38MAPK表达的相关性：方法每例标本用p38MAPK染色，显微镜观察阳性细胞表达分布情况并计算平均数。结果采用SPSS8．0 for windows统计软件进行分析。结果中医分型与Va8MAPK的表达呈正相关。结论慢性鼻炎鼻黏膜p38MAPK的表达在中医证型中存在明显差异，气虚证呈低表达，血瘀证呈高表达，

Abstract: OBJECTIVE To demonstrate the correlation between the transformation of syndromes of chronic rhinitis and the expression of the nose mucous membrane p38MAPK. METHOD Each sample was stained with p38MAPK and microscope was used to observe the distribution of the positive cells and calculate the average. The results were analyzed with the computer software SPSS 8.0 for windows. RESULT The transformation from the qi deficiency syndrome to the blood stasis syndrome was found to be directly correlated with p38MAPK expression. CONCLUSION During the process of transformation from the qi deficiency syndrome to the blood stasis syndrome, p38MAPK is one of the important factors.

[1]	田勇泉,孙爱华.耳鼻咽喉科学[M].北京:人民卫生出版社,2001.9.
[2]	王德鉴,干祖望.中医耳鼻喉科学[M].上海:上海科学技术出版社,2002.7.
[3]	李同丽,李潭,张革化,等.p38丝裂原素活化蛋白激酶在慢性鼻-鼻窦炎黏膜中的表达及意义[J].中华耳鼻咽喉科杂志,2004,39(10):626.
[4]	Seger R,Krebs EG.The MAPK signaling cascade[J].FASEB J,1995,9:726.
[5]	Ono K,Han J.The p38 signal transduction pathway:activation and function[J].CellSignal,2000,12:1.
[6]	Herlaar E,Brown Z.p38 MAPK signalling cascades in inflammatory disease[J].Mol MedToday,1999,5:439.
[7]	王东方,干祖望,曹济航.中药治疗对慢性鼻炎鼻腔生理功能的影响[J].辽宁中医杂志,1996,23(2):76.
[8]	王东方,干祖望,曹济航,等.慢性鼻炎舌诊和血液流变学观察与血瘀关系探讨[J].中国中西医结合耳鼻咽喉科杂志,1996,4(3):106.
[9]	王东方,干祖望,曹济航,等.慢性鼻炎鼻腔腺体分泌功能与气虚相关性探讨[J].辽宁中医杂志,1997,24(4):147.
[10]	王东方,吴雪萍,干祖望,等.慢性鼻炎鼻腔纤毛输送功能与气虚相关性研究[J].辽宁中医杂志,1996,23(9):392.
[11]	王东方,干祖望,王宁皎,等.慢性鼻炎鼻分泌物sIgA含量与气虚相关性研究[J].中国中西医结合耳鼻咽喉科杂志,1999,7(4):161.