HPLC测定北细辛不同部位及穴贴定喘膏中马兜铃酸A的含量

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基金项目: 江苏省教育厅高新技术产业化课题(JH02-103)

HPLC Determination of Content of Aristolochic Acid A in Different Parts of Herba cum Radice Asari and in Xuetie Dingchuan Plaster

New Drug and Marine Drug Research and Development Center of Nanjing University of Traditional Chinese Medicine, , 210029, China

摘要: 目的测定细辛不同药用部位及其制剂中马兜铃酸A的含量。方法采用HPLC方法,测定不同来源、不同批次的细辛药材;不同药用部位及其制剂定喘穴贴膏中马兜铃酸A的含量。结果细辛地上部分粗粉中马兜铃酸A含量高于细辛根茎粗粉中马兜铃酸A含量,制剂中没有检出马兜铃酸A。结论2005年版的《中国药典》将细辛药用部位由全草改为根茎是合理的,穴贴定喘膏未检出马兜铃酸A。
- 细辛 /
- 马兜铃酸A /
- 穴贴定喘膏 /
- HPLC
Abstract: OBJECTIVE To determine the content of Aristolochic Acid A in different parts of Herba cum Radice Asari and in Xuetie Dingchuan Plaster.METHOD HPLC method was used in the determination.RESULT The content of aristolochic acid A in the parts of Herba cum Radice Asari above the ground was higher that in the root part,and aristolochic acid A was not detected in the preparation.CONCLUSION It is reasonable that the 2005 edition of Chinese Pharmacopoeia specifies that the medicinal part of Herba cum Radice Asari is the root part,not the whole plant.Aristolochic acid A was not detected in Xuetie Dingchuan Plaster.
- Herba cum Radice Asari /
- aristolochic acid A /
- Xuetie Dingchuan Plaster /
- HPLC

[1]	吴琳,苏维辉,周士臻,等.反相高效液相色谱法测定关木通水煎剂中马兜铃酸A的含量[J].中国药房,2002,13(9):551.
[2]	吴艳蓉,贾凌云,高福坤,等.不同产地辽细辛中马兜铃酸的痕量检测[J].中药研究与信息,2005,7(1):9.

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