鼻炎喷雾剂对变应性鼻炎模型大鼠的药效学研究

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名

邮箱

手机号码

标题

留言内容

验证码

基金项目: 上海市科委资助项目

Pharmacodynamic Study of Effect of Rhinitis Spray on Rat Models with Allergic Rhinitis

Pharmacology College of Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

摘要: 目的探讨中药鼻炎喷雾剂对变应性鼻炎模型大鼠的药效作用。方法以10%TDI橄榄油溶液滴鼻造成变应性鼻炎大鼠模型,经鼻腔给中药鼻炎喷雾剂治疗,并以立复汀鼻喷雾剂为对照,观察药物对大鼠症状评分、病理改变、鼻黏膜及血清组胺含量的影响。结果中药鼻炎喷雾剂能有效地抑制变应性鼻炎大鼠鼻黏膜病理改变,减少鼻黏膜及血清中组胺含量,从而达到对变应性鼻炎的治疗作用。结论中药鼻炎喷雾剂具有明显抑制或消除变应性鼻炎症状的作用。
- 中药鼻炎喷雾剂 /
- 变应性鼻炎 /
- 药效学
Abstract: OBJECTIVE To explore into the pharmacodynamic effect of rhinitis spray on rat models with allergic rhinitis. METHOD Allergic rhinitis rat models were made using 10% TDI olive oil,which were then treated with rhinitis spray made from Chinese medicine,compared with a control group treated with Livostin nose spray. RESULT The rhinitis spray made from Chinese medicine could effectively inhibit the pathological changes of nose membrane of rats with allergic rhinitis and reduce the content of thylamine in the nose membrane.CONCLUSION The rhinitis spray made from Chinese medicine has good effect in inhibiting or removing the symptoms of allergic rhinitis.
- rhinitis spray /
- allergic rhinitis /
- pharmacodynamics

[1]	Tanaka K,Okamoto Y,Nagaya Y,et al.S nasal allergy model developed in the Guinea pig by intranasal application of 2,4 -toluene diisocyanate[J].Int Archs Allegy Appl Immunol,1998,85:392.
[2]	赵秀杰.鼻超敏反应实验模型的建立[J].中华耳鼻咽喉科杂志,1993,28(1):17.
[3]	窦淑云,符云峰.血及组织中组织胺含量的荧光测定法[J].中华医学检验杂志,1981,4(2):100.

点击查看大图