文章摘要
杨玲娟,宋蒙蒙,狄留庆,丁康.天然黄酮类化合物对芳香烃受体的调控作用研究进展[J].南京中医药大学学报,2021,37(6):958-964.
天然黄酮类化合物对芳香烃受体的调控作用研究进展
Recent Progress of Natural Flavonoids as Ligand on Aryl Hydrocarbon Receptor
  
DOI:
中文关键词: 关键词:黄酮  芳香烃受体  配体
英文关键词: flavonoids  aryl hydrocarbon receptor  ligands
基金项目:
作者单位
杨玲娟1,宋蒙蒙2,狄留庆2,丁康3 1.江苏省生产力促进中心江苏 南京 2100422.南京中医药大学药学院江苏 南京 210023
3.南京中医药大学附属南京市中医院
江苏 南京 210001 
摘要点击次数: 26
全文下载次数: 49
中文摘要:
      黄酮类成分广泛存在于植物、中草药中,具有多种药理学活性,近年来的研究表明,它可以通过调控多种信号通路发挥其抗炎、抗氧化、化学预防等作用。笔者聚焦在药物代谢、免疫调节、化学预防中具有重要作用的芳香烃受体,在系统综述芳香烃受体功能及调控模式基础上,总结了不同黄酮类化合物对芳香烃受体的激动或拮抗作用,并对常见黄酮成分通过芳香烃受体发挥其抗肿瘤、抗溃疡性结肠炎、抗特异性皮炎的独特作用机制进行了介绍,并展望了黄酮类化合物在上述疾病治疗中潜在前景和局限性。
英文摘要:
      Flavonoids are widely existed in plants and herbs, which have a variety of pharmacological activities. Recent studies have shown that they can exert anti-inflammatory, antioxidant, and chemopreventive effects by regulating various signaling pathways. In this paper, we focused on the aryl hydrocarbon receptor, which plays an important role in drug metabolism, immunomodulation, and chemoprevention. After a systematic review of the functions and regulation modes of aryl hydrocarbon receptor, we summarized the agonistic or antagonistic effects of different flavonoids on aryl hydrocarbon receptor and elaborated their anti-tumor, anti-ulcerative colitis, and anti-atopic dermatitis effects by activating aryl hydrocarbon receptor through unique mechanisms. Furthermore, the potential prospects and limitations of flavonoids in the treatment of the above diseases were also presented.
查看全文   查看/发表评论  下载PDF阅读器
关闭
微信公众号