文章摘要
陈婕,殷燕云,谈勇,黄文青,邹奕洁,唐培培,王飞虹.国医大师夏桂成“7、5、3奇数律”与体外受精-胚胎移植扳机时机相关性的临床研究[J].南京中医药大学学报,2021,37(6):847-852.
国医大师夏桂成“7、5、3奇数律”与体外受精-胚胎移植扳机时机相关性的临床研究
Clinical Study on the Correlation between "Seven-Five-Three" Odd Number Regular Pattern by National Distinguished Master Xia Guicheng and the Trigger Timing of in vitro Fertilization-Embryo Transfer
  
DOI:
中文关键词: 关键词:中医女性生殖节律  奇数律  辅助生殖  扳机
英文关键词: female reproductive regular pattern in Chinese medicine  odd number regular pattern  assisted reproduction  trigger
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作者单位
陈婕1,殷燕云1,谈勇2,黄文青2,邹奕洁1,唐培培1,王飞虹1 1.南京中医药大学附属医院/江苏省中医院江苏 南京 210029
2.南京中医药大学第一临床医学院江苏 南京 210023 
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中文摘要:
      目的 观察体外受精/卵胞浆内单精子注射-胚胎移植(In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer,IVF/ICSI-ET)长方案周期中最佳扳机日是否与国医大师夏桂成教授提出的“7、5、3奇数律”相符,以及对卵泡及胚胎发育情况及妊娠结局的影响。方法 回顾性分析426例因女方因素首次接受IVF/ICSI-ET长方案周期,根据促性腺激素(Gonadotropin,Gn)启动日至扳机日是否符合“7、5、3奇数律”,分为数律扳机组与非数律扳机组,比较Gn天数、Gn用量及获卵率、受精率、2原核(2 Pronucleus,2PN)率、可移植胚胎率、临床妊娠率、活产率等。结果 ①按“7、5、3奇数律”扳机组186例,其获卵率、2PN率、可移植胚胎率、临床妊娠率、活产率均显著高于非数律扳机组(P<0.05,P<0.01)。②3数律亚组中,按数律扳机组受精率显著高于非数律扳机组(P<0.01);5数律亚组中,按数律扳机组Gn天数及Gn总量显著低于非数律扳机组(P<0.01),按数律扳机组获卵率、可移植胚胎率、临床妊娠率均显著高于非数律扳机组(P<0.05,P<0.01);7数律亚组中,按数律扳机组可移植胚胎率显著高于非数律扳机组(P<0.05)。结论 国医大师夏桂成教授提出的“7、5、3奇数律”适用于IVF/ICSI-ET长方案周期扳机日的确立,按7、5数律扳机可提高可移植胚胎率,5数律扳机可升高临床妊娠率与活产率,3数律扳机可增加受精率。
英文摘要:
      OBJECTIVE To observe whether the optimal trigger day in in vitro fertilization/intra cytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) long protocol cycles is conformed to the "seven-five-three" odd number regular pattern by national distinguished master Xia Guicheng, as well as its effect on follicular and embryonic development and pregnancy outcome. METHODS A total of 426 cases who underwent IVF/ICSI-ET for the first time due to female factor, they were divided into numerical trigger group and non-numerical trigger group according to whether the gonadotropin (Gn) initiation date to the trigger date conformed to the seven-five-three odd number regular pattern. In addition, we compared the Gn days, Gn dosage, egg acquisition rate, fertilization rate, 2 pronucleus (2 PN) rate, transferable embryo rate, clinical pregnancy rate, and live birth rate. RESULTS ①The egg acquisition rate, 2PN rate, transferable embryo rate, clinical pregnancy rate and live birth rate of 186 cases in the seven-five-three odd number regular pattern trigger group were significantly higher than those in the non-numerical trigger group (P<0.05, P<0.01). ②As to "three" regular pattern subgroup, the fertilization rate was significantly higher in the numerical trigger group than that in the non-numerical trigger group (P<0.01); As to "five" regular pattern subgroup, the Gn days and the total number of Gn in the numerical trigger group were significantly lower than those in the non-numerical trigger group (P<0.01); The egg acquisition rate, embryo transferability rate and clinical pregnancy rate were significantly higher in the numerical trigger group than those in the non-numerical trigger group (P<0.05, P<0.01); As to "seven" regular pattern subgroup, the embryo transferability rate in the numerical trigger group was significantly higher than that in the non-numerical trigger group (P<0.05). CONCLUSION The seven-five-three odd number regular pattern proposed by Xia Guicheng, a national distinguished master, is applicable to the establishment of the trigger day of IVF/ICSI-ET long protocol cycle, and the transferable embryo rate can be improved by the seven and five regular pattern triggers. In addition, the five regular pattern trigger can increase the clinical pregnancy and live birth rates, and the three regular pattern trigger can increase the fertilization rate.
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