文章摘要
陆喜荣,彭惠平,徐倩菲,徐进康.芪竹方改善早期胃癌ESD后症状及预防复发的临床观察[J].南京中医药大学学报,2020,36(4):454-457.
芪竹方改善早期胃癌ESD后症状及预防复发的临床观察
Clinical Observation on the Effects of Qizhu Formula in Improving Postoperative Symptoms of Early Gastric Cancer and Preventing the Recurrence of Gastric Cancer
  
DOI:
中文关键词: 关键词:芪竹方  早期胃癌  胃黏膜剥离术  复发
英文关键词: Qizhu formula  early gastric cancer  gastric endoscopic submucosal dissection  recurrence
基金项目:
作者单位
陆喜荣,彭惠平,徐倩菲,徐进康 南京中医药大学附属昆山市中医医院江苏 昆山 215300 
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中文摘要:
      目的 观察芪竹方改善早期胃癌胃黏膜剥离术(ESD)后气阴两虚型症状及预防胃癌复发的临床疗效。方法 共84例早期胃癌ESD后气阴两虚证患者随机分成2组,其中脱落6例,纳入治疗组39例,对照组39例。对照组给予胃复春治疗,治疗组予芪竹方治疗,持续治疗1 a。观察2组临床复发率、胃镜像糜烂灶、病理积分、中医证候积分及癌胚抗原(CEA)变化。结果 治疗后,治疗组在复发率方面低于对照组(5.13% vs. 20.51%,P<0.05),治疗组可以较好地减少糜烂灶(P<0.01),降低病理积分及CEA水平(P<0.01),改善临床症状(P<0.01),均优于对照组(P<0.05)。结论 芪竹方可以较好地改善临床症状,减少胃黏膜糜烂、肠化生及异型增生,降低复发率,临床疗效显著。
英文摘要:
      OBJECTIVE To observe the efficacy of Qizhu formula in improving qi and yin deficiency symptoms after gastric endoscopic submucosal dissection (ESD) for patients with early gastric cancer and preventing the recurrence of gastric cancer. METHODS 84 patients with early gastric cancer who had deficiency of qi and yin symptoms were randomly divided into 2 groups with 6 expulsion cases, 39 cases in the treatment group and 39 cases in the control group after ESD. The control group was treated with Weifuchun pills, while the treatment group was treated with Qizhu decoction for one year. Clinical recurrence rate, gastroscopy erosions, pathological scores, traditional Chinese medicine (TCM) syndrome scores and carcinoembryonic antigen (CEA) changes were observed in the 2 groups. RESULTS After the treatment, the recurrence rate was lower in the treatment group than that in the control group (5.13% vs 20.51%, P<0.05). Compared with the control group, the treatment group had less clinical symptoms (P<0.01), erosions (P<0.05), lower pathological scores (P<0.05) and CEA (P<0.05), as well as significant relieves in stomachache, poor digestion and acid reflux symptoms (P<0.05). CONCLUSION Qizhu decoction can improve clinical symptoms, reduce gastric mucosal erosion, intestinal metaplasia and hyperplasia, and reduce the recurrence rate of gastric cancer with a remarkable therapeutic effect.
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