文章摘要
张磊,金华,王亿平,王东,文艳,刘珂.清肾颗粒对慢性肾衰竭患者肾功能及血清α-平滑肌动蛋白和E-钙粘蛋白的影响[J].南京中医药大学学报,2019,35(6):651-654.
清肾颗粒对慢性肾衰竭患者肾功能及血清α-平滑肌动蛋白和E-钙粘蛋白的影响
A Clinical Study on the Effect of Qingshen Capsule on Chronic Kidney Failure Patients' Kidney Function, Serum α-Smooth Muscle Actin and E-Cadherin
  
DOI:
中文关键词: 关键词:慢性肾衰竭  湿热证  清肾颗粒  α-平滑肌动蛋白  E-钙粘蛋白
英文关键词: chronic kidney failure  dampness-heat syndrome  Qingshen capsule  α-smooth muscle actin  E-cadherin
基金项目:
作者单位
张磊1,金华2,王亿平2,王东2,文艳1,刘珂1 1.安徽中医药大学研究生院安徽 合肥 2300382.安徽中医药大学第一附属医院安徽 合肥 230031 
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中文摘要:
      目的 观察中药复方清肾颗粒对于慢性肾衰竭湿热证患者肾功能及血清α-平滑肌动蛋白和E-钙粘蛋白的影响。方法 符合纳入标准的70例慢性肾衰竭湿热证患者,随机分为治疗组和对照组各35例,治疗组在对照组治疗方案基础上加用清肾颗粒口服,疗程12周。观察2组中医证候疗效及临床疗效;治疗前后血肌酐(Scr)、肾小球滤过率(eGFR)、血清α-平滑肌动蛋白(α-SMA)、E-钙粘蛋白(E-cadherin)水平变化。结果 研究最终完成68例(治疗组、对照组各34例)。治疗后治疗组中医证候疗效及临床疗效均优于对照组(P<\i><0.05);治疗组患者Scr、eGFR水平明显改善(P<\i><0.05),优于对照组(P<\i><0.05);治疗组血清α-SMA、E-cadherin水平下降(P<\i><0.05),比对照组低(P<\i><0.05);治疗组患者服用清肾颗粒后未出现药物不良副作用。结论 清肾颗粒能够减轻慢性肾衰竭湿热证患者临床症状,降低Scr水平,同时下调慢性肾衰竭湿热证患者血清α-SMA、E-cadherin水平,安全性良好。
英文摘要:
      OBJECTIVE To observe the effect of Chinese herbal compound Qingshen capsule on chronic kidney failure patients' kidney function, serum α-smooth muscle actin (α-SMA)and E-cadherin. METHODS 70 chronic kidney failure patients with dampness-heat syndrome were randomly divided into the treatment group and the control group with35 in each. Based on the therapy for the control group, the treatment group was also given Qingshen capsule. The course lasted 12 weeks. After that, 68 patients completed the follow-up, each group 34 cases. The observing parameters included curative effect of traditional Chinese medicine (TCM) syndrome, clinical effect, the level of serum creatinine (Scr),e-GFR serum α-SMA and E-cadherin before and after treatment. RESULTS After treatment, TCM syndrome effect and clinical effect of the treatment group was better than that of the control group (P<\i><0.05). As for the level of Scr and eGFR, patients in the treatment group has much improved (P<\i><0.05) than those in the control group (P<\i><0.05). The level of serum α-SMA and E-cadherin declined (P<\i><0.05), lower than that of control group (P<\i><0.05). Patients in the treatment group hadn't been exposed to the side effects of Qingshen capsule. CONCLUSION Qingshen capsule can relive clinical symptoms for chronic kidney failure patients with dampness-heat syndrome, more precisely, degrading Scr level, serum α-SMA and E-cadherin and having good safety.
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