文章摘要
郑劼,包凯帆,李伟,袁为远,许一凡,余雪瑞,张雨恒,周祎靖,陈艳燕,洪敏.基于益气固表功效探讨玉屏风散抗过敏复发的作用及机制[J].南京中医药大学学报,2019,35(5):606-612.
基于益气固表功效探讨玉屏风散抗过敏复发的作用及机制
Effects and Mechanisms of Yupingfeng San on Anti-Allergic Recurrence Based on "Yiqi Gubiao" Efficacy
  
DOI:
中文关键词: 关键词:玉屏风散  益气固表  过敏性疾病  抗过敏复发
英文关键词: Yupingfeng San  Yiqi Gubiao  allergic disease  anti-allergic recurrence
基金项目:
作者单位
郑劼1,2,包凯帆1,李伟1,袁为远1,许一凡1,余雪瑞1,张雨恒1,周祎靖1,陈艳燕1,洪敏1 1.南京中医药大学药学院江苏省中药药效与安全性评价重点实验室江苏 南京 2100232.南京中医药大学医学与生命科学学院江苏 南京 210023 
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中文摘要:
      过敏性疾病反复发作是临床亟待解决的难题,玉屏风散在防治过敏性疾病中具有独特优势,但其作用机制尚未完全阐释。该文基于中医药益气固表重要治法,探讨玉屏风散治疗过敏性疾病及抗过敏复发的作用及机制;明确该方在过敏性疾病治疗中尤其是抗过敏复发中的独特优势;通过细胞萃取色谱法及血清药理学筛选该方中主要的活性成分;通过网络药理学对该方活性成分及作用靶点进行预测分析;并分别从调控、维持免疫稳态和修复上皮屏障功能的角度,深入探讨和理解益气固表的科学内涵。
英文摘要:
      Recurrent allergic disease is an inevitable clinical challenge. Yupingfeng San (YPFS) clinically shows unique advantages in the prevention and treatment of allergic diseases, however its mechanism has not been fully elucidated. Based on the traditional Chinese medicine treatment strategy "Yiqi Gubiao", our research group explored the effects and mechanisms of YPFS in the treatment of allergic diseases and anti-allergic recurrence. We confirmed its unique advantages in treating of allergic diseases, especially anti-allergic relapse. The main active components of YPFS were screened by cell binding combined with HPLC-MS and serum pharmacology. The active components and their potential targets were predicted and analyzed by network pharmacology. From the perspective of regulating and maintaining immune homeostasis as well as repairing epithelial barrier function, the scientific connotation of "Yiqi Gubiao" was further explored and understood.
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