文章摘要
张毅楠,胡立宏.基于中药量丰成分的药物发现研究[J].南京中医药大学学报,2019,35(5):596-600.
基于中药量丰成分的药物发现研究
Drug Discovery Based on Naturally Abundant Ingredients
  
DOI:
中文关键词: 关键词:中药  量丰成分  药物发现
英文关键词: Chinese medicine  naturally abundant ingredients  drug discovery
基金项目:
作者单位
张毅楠,胡立宏 南京中医药大学药学院江苏省中药功效物质重点实验室江苏 南京 210023 
摘要点击次数: 184
全文下载次数: 80
中文摘要:
      从中医药临床实践经验总结中,通过科学研究发现天然先导结构,进一步通过活性优化、成药性优化转化为创新药物,是实现中药现代化的有效途径。大量研究显示单味中药传统功效的物质基础通常是其量丰的特征性成分。通过对青蒿素、三氧化二砷、根皮苷等几种量丰特征性成分的活性发现、作用机制揭示、结构优化,最终开发成药物,总结了它们的成功经验,可为基于中药量丰成分的药物发现研究者提供可借鉴的研究思路。
英文摘要:
      From the clinical practices and summary of Chinese medicine, it has been proved that the discovery of lead compounds from natural medicine and followed by structural optimization toward innovative drugs is one of the most effective strategies for the modernization of Chinese medicine. A lot of research have exhibited that the chief pharmacological materials of single Chinese herb are always the naturally-abundant and structural featured constituent(s). In this perspective, we summarized the successful research stories of such constituents like artemisinin, arsenic trioxide and phlorizin, including discovery of the pharmacological activity, study of the molecular mechanism, structural optimization and development of innovative drugs. These experiences may contribute useful ideas for the researchers who are working in the field of drug discovery based on naturally abundant ingredients.
查看全文   查看/发表评论  下载PDF阅读器
关闭
微信公众号