文章摘要
严花,单进军,赵霞.代谢组学和脂质组学在哮喘研究中的应用进展[J].南京中医药大学学报,2019,35(5):552-561.
代谢组学和脂质组学在哮喘研究中的应用进展
Application and Prospect on Metabolomics and Lipidomics in Asthma
  
DOI:
中文关键词: 关键词:代谢组学  脂质组学  哮喘  应用
英文关键词: metabolomics  lipidomics  asthma  application
基金项目:
作者单位
严花1,2,单进军2,赵霞1,2 1.南京中医药大学附属医院江苏 南京 210029
2.江苏省儿童呼吸疾病中医药重点实验室南京中医药大学中医儿科学研究所江苏 南京 210023 
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中文摘要:
      哮喘是常见的慢性炎症性疾病,以喘息、胸闷、咳嗽、呼吸急促为主要表现。其发病机制复杂,且具有异质性的特点,给诊断和治疗带来困难。代谢组学和脂质组学可以从机体内小分子代谢物及代谢通路水平探索哮喘的发病机制,指导诊断和治疗。同时,代谢组学和脂质组学符合中医学整体观念,适用于对中医证型客观化和标准化的研究,并为中医药治疗哮喘的可行性提供依据。该文对近年来代谢组学和脂质组学在生物标记物发现和代谢图谱构建的进展进行了综述,旨在为哮喘发病机制、诊断和治疗提供新思路。
英文摘要:
      Asthma is a common chronic inflammatory airway disease, usually characterized by the history of respiratory symptoms such as wheeze, cough, chest tightness and shortness of breath that vary over time and in intensity. The pathogenesis of asthma is complex and heterogeneous, which makes it difficult to diagnose and treat. Metabolomics and lipidomics can explore the pathogenesis of asthma and guide the diagnosis and treatment from the level of small molecule metabolites and metabolic pathways. Furthermore, metabolomics and lipidomics are in line with the Chinese medicine overall observation theory. They are promising laboratory tools for the study of the standardization and objectivity of traditional Chinese medicine (TCM) syndromes, thus metabolomics and lipidomics can potentially provide useful information for the feasibility of TCM treatment. This paper reviews the application of metabolomics and lipidomics to provide new ideas for the pathogenesis, diagnosis and treatment of asthma by discovering various biomarkers and perturbed pathways in recent years.
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