文章摘要
刘成勇,吴文忠,房翳恭,秦珊,刘兰英,王和生,张聪,陈栋,史丹.白芥子涂方穴位贴敷防治支气管哮喘的临床研究[J].南京中医药大学学报,2018,34(6):565-568.
白芥子涂方穴位贴敷防治支气管哮喘的临床研究
Clinical Research on the Prevention and Treatment of Bronchial Asthma by Acupoint Application of Baijiezi Tufang
  
DOI:
中文关键词: 关键词:白芥子涂方  穴位贴敷  皮肤反应  哮喘
英文关键词: Baijiezi tufang  acupoint application  skin irritation  asthma
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作者单位
刘成勇1,吴文忠1,房翳恭2,秦珊1*,刘兰英1,王和生1,张聪1,陈栋1,史丹1 1.南京中医药大学附属医院江苏 南京 2100292.中国中医科学院针灸研究所北京 100700 
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中文摘要:
      目的 观察白芥子涂方穴位贴敷防治支气管哮喘的疗效,以及疗效与皮肤反应之间的关系。方法 所纳入的支气管哮喘患者于三伏天期间进行贴敷,第1年基线期所有患者在(肺俞、心俞、膈俞)对照穴位上进行低剂量药物穴位贴敷,第2年患者随机分为对照组、安慰剂组和试验组,每组30例,对照组继续在对照穴位上进行低剂量药物穴位贴敷,安慰剂组在肺俞、心俞、膈俞进行低剂量药物穴位贴敷,试验组在肺俞、心俞、膈俞进行正常剂量药物穴位贴敷,观察穴位贴敷治疗后患者哮喘发作次数、肺功能以及皮肤反应的变化情况。结果 基线期试验组、安慰剂组、对照组3组患者哮喘发作次数比较,差异无统计学意义。试验期试验组患者哮喘发作次数明显减少,差异具有统计学意义(P<0.01),安慰剂组、对照组患者哮喘发作次数无明显变化,差异无统计学意义。2015年、2016年初伏前比较,3组患者肺功能(MMEF、FEF25、FEF50、FEF75)无明显差异;2017年初伏前,试验组肺功能明显改善(P<0.05~0.01),优于安慰剂组、对照组(P<0.05~0.01)。与基线期穴位贴敷相比,试验期试验组患者贴敷部位皮肤刺激性强度明显增强,差异具有统计学意义(P<0.01),安慰剂组、对照组患者贴敷部位皮肤刺激性强度差异无统计学意义。结论 白芥子涂方穴位贴敷能有效改善哮喘患者的小气道功能,从而减少哮喘的发作,其疗效与贴敷后出现皮肤刺激性反应有关。
英文摘要:
      OBJECTIVE To observe the prevention and treatment effect of bronchial asthma by the acupoint application of Baijiezi (Semen Sinapis) tufang, and the relationship between efficacy and skin irritation. METHODS The included bronchial asthma patients were applied during the dog days, all patients in the first year of the baseline stage were given low-dose medicine acupoints application on the control points of Fei shu (BL 13), Xin shu (BL 15), Ge shu (BL 17).In the second year, the patients were randomized into a control group, a placebo group and a experimental group, 30 cases in each one. The control group continued to apply low-dose medicine on the control acupoints, and the placebo group was given low-dose medicine acupoint application on Fei shu(BL 13), Xin shu (BL 15), Ge shu (BL 17). The experimental group were treated with normal does in Fei shu (BL 13), Xin shu (BL 15), Ge shu (BL 17). Observed the changes of asthma attack number, lung function and skin reaction after acupoint application treatment. RESULTS There was no significant difference in the number of asthma attacks between the baseline group, the placebo group and the control group. The number of asthma attacks was significantly reduced in the experimental group, the difference was statistical significant (P<0.01). There was no significant change in the number of asthma attacks between the placebo group and the control group. Compared with the baseline period, there was no significant difference in lung function (MMEF, FEF25, FEF50, FEF75) between the experimental group, the placebo group and the control group before the trial period. Compared with before the baseline period and the trial period, the lung function of the experimental group was significantly improved after the acupoint application treatment, the difference was statistical significant (P<0.05, P<0.01). But the lung function of the placebo group and the control group was not significantly improved, the difference was no statistical significant. Compared with baseline period acupoint application, the skin irritation was significantly enhanced in the experimental group of trial period, the difference was statistical significant (P<0.01).The difference in skin irritation between the placebo group and the control group has no statistical significant. CONCLUSION Baijiezi (Semen Sinapis) tufang acupoint application can effectively improve the small airway function of asthma patients, thus reducing the number of asthma attacks. The treatment effect is related to the skin irritation after the application.
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