文章摘要
王彬1,2,蔡皓1,2,秦昆明1,2,3,张淼1,2,王玉3,金俊杰3,蔡宝昌1,2,3*.不同煎煮时间对解郁顺心汤中无机元素含量的影响[J].南京中医药大学学报,2016,32(1):83-86.
不同煎煮时间对解郁顺心汤中无机元素含量的影响
Effects of Different Decocting Time on the Content of Inorganic Element in Jieyu Shunxin Decoction
  
DOI:
中文关键词: ICP-AES  微量元素  解郁顺心汤
英文关键词: ICP-AES  trace elements  Jieyu Shunxin Decoction
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作者单位
王彬1,2,蔡皓1,2,秦昆明1,2,3,张淼1,2,王玉3,金俊杰3,蔡宝昌1,2,3* 1.南京中医药大学药学院江苏 南京 2100232.国家中医药管理局中药炮制标准重点研究室江苏 南京 2100233.南京海昌中药集团有限公司江苏省企业研究生工作站江苏 南京 210061 
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中文摘要:
      目的 建立电感耦合等离子体原子发射光谱法(ICP-AES)测定解郁顺心汤中不同元素的方法,研究不同的煎煮时间对解郁顺心汤中元素煎出的影响。方法 采用HNO3/H2O2微波消解制样,再应用ICP-AES法同时测定解郁顺心汤在煎煮时间为30、60、90 min的水煎液中K、Ca、Na、Mg、Al、Zn、Fe、Sn、B、Li、Sr、Cd和As 13种元素的含量组成并进行分析。结果 煎煮时间为30 min时,解郁顺心汤中的各元素不能够完全析出,煎煮60 min各元素基本煎出。解郁顺心汤中含有丰富的元素,其中常量元素中K元素的含量最高,微量元素中Zn元素含量最高。煎煮90 min,未检测到Cd和As这2种元素。各元素的线性关系良好,r均大于0.999 0,精密度、稳定性和重复性试验的RSD均符合定量分析要求;加标回收率为95.07%~100.83%,RSD<3%。结论 为了减少煎煮时间且将解郁顺心汤中的各元素尽可能的煎出,煎煮时间应控制在60 min。实验结果为解郁顺心汤物质基础和药效学研究提供一定依据。
英文摘要:
      OBJECTIVE To determine mineral elements content in Jieyu Shunxin Decoction (JYSXD) by ICP-AES,and study the effect of different decocting time on the solution of mineral elements in JYSXD. METHODS Mineral elements (K, Ca, Na, Mg, Al, Zn, Fe, Sn, B, Li, Sr, Cd and As) in JYSXD which was boiled for 30, 60, 90 min, respectively, were detected by ICP-AES after HNO3/H2O2 digestion. RESULTS After JYSXD was boiled for 30 min, each element was not able to completely precipitated. However, after the decoction was boiled for 60 min, all the elements were completely precipitated. K, Ca, Na, Mg, Al, Zn, Fe, Sn, B, Li and Sr were detected, while Cd and As were not found. Among them, K was the highest in the content of major elements and Zn was the highest in trace elements. Each mineral elements in JYSXD showed good linear relationship (r>0.999 0), RSD of precision, stability and repeatability test all satisfied the requirement of quantitative analysis. The recovery was 95.07%~100.83% (RSD<3%). CONCLUSION In order to reduce the decocting time and maintain the solution of mineral elements in JYSXD as much as possible, the decocting time should be controlled at 60 min. The experimental results provide basis for material basis and pharmacodynamics study of Jieyu Shunxin Decoction.
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