文章摘要
徐珊,康安,彭琳秀,单进军,汪受传.基于GC-MS的温运合剂及其君药麸炒苍术水提物对小鼠脾虚泄泻的作用研究[J].南京中医药大学学报,2018,34(2):181-184.
基于GC-MS的温运合剂及其君药麸炒苍术水提物对小鼠脾虚泄泻的作用研究
Effect of Wenyun Mixture and Bran Stir-Baked Atractylodis Water Extract on Spleen-deficiency Diarrhea in Mice Based on GC-MS
投稿时间:2017-10-23  
DOI:
中文关键词: 温运合剂  脾虚泄泻  短链脂肪酸  麸炒苍术
英文关键词: Wenyun mixture  spleen deficiency diarrhea  short chain fatty acid  bran fried atractylodes
基金项目:
作者单位
徐珊1*,康安2,彭琳秀2,单进军3,汪受传1,3 1.南京中医药大学附属医院江苏 南京 
210029
2.南京中医药大学药学院江苏 南京 
210023
3.南京中医药大学第一临床医学院江苏 南京 
210023
 
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中文摘要:
      探究温运合剂及其君药麸炒苍术水提物对脾虚泄泻模型小鼠的治疗作用。方法 选用番泻叶水煎液制备大鼠脾虚模型。检测温运合剂及其麸炒苍术水提物不同剂量对粪便内短链脂肪酸(SCFAs)水平的影响。结果 与模型组比较,麸炒苍术水提物低剂量组小鼠粪便中的丙酸水平明显升高,麸炒苍术水提物高剂量组小鼠粪便中的丙酸、异戊酸水平明显升高,温运合剂高低剂量组均能显著提高小鼠粪便中的乙酸、丙酸、异丁酸水平。结论 温运合剂及其君药麸炒苍术水提物均能明显拮抗番泻叶所致小鼠脾虚泻,提高短链脂肪酸水平可能是温运合剂及其君药麸炒苍术水提物发挥运脾止泻功效的作用机制之一。
英文摘要:
      OBJECTIVE To explore the effect of Wenyun mixture and bran stir-baked Atractylodis water extract on Spleen-deficiency Diarrhea in mice. METHODS The spleen deficiency mouse models were established by extract of Sennae Folium. Fecal short chain fatty acids (SCFAs) levels were detected and measured after treatment of different doses of Wenyun mixture and bran stir-baked Atractylodis water extract. RESULTS Compared with the model group, propionic acid level in mice feces was increased in low dose of bran fried Atractylodes water extract group significantly, propionic acid and isovaleric acid level in mice feces were increased in high dose of bran fried Atractylodes water extract group significantly, acetic acid, propionic acid and butyric acid level in mice feces were increased in high dose of Wenyun mixture group significantly. CONCLUSION Wenyun mixture and bran fried Atractylodes water extract could obviously improve short chain fatty acid level to transform spleen Qi and stop diarrhea.
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