文章摘要
李道明,王蓉,谢菁.黄芪桂枝五物汤治疗奥沙利铂化疗后周围神经毒性24例[J].南京中医药大学学报,2014,30(2):186-188.
黄芪桂枝五物汤治疗奥沙利铂化疗后周围神经毒性24例
Clinical Study on Huangqi Guizhi Wuwu Decoction Treating the Neuro-sensory Toxicity Caused by Oxaliplatin
投稿时间:2013-12-21  修订日期:2014-01-20
DOI:
中文关键词: 黄芪桂枝五物汤  奥沙利铂  周围神经毒性
英文关键词: Huangqi Guizhi Wuwu Decoction  oxaliplatin  neuro-sensory toxicity
基金项目:
作者单位
李道明,王蓉,谢菁 苏州大学附属第一医院江苏 苏州 
215006 
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中文摘要:
      目的 观察黄芪桂枝五物汤减轻对奥沙利铂神经毒性的疗效。方法 对接受FOLFOX6方案化疗的48例大肠癌患者,随机分为对照组和治疗组。对照组单接受化疗,治疗组在接受奥沙利铂化疗的同时配合服用黄芪桂枝五物汤中药治疗。奥沙利铂引起的周围神经毒性评定参考Levi专用标准。结果 治疗组24例,发生周围神经毒性1级8例,2级1例,3级0例,4级0例,总发生率为37.5%。对照组24例中发生周围神经毒性1级13例,2级3例,3级3例,4级0例,总发生率为79.17%。2组比较,治疗组在接受奥沙利铂治疗时神经毒性的发生率及3~4级毒性反应发生程度明显减低,差异有统计学意义(P<0.01)。结论 黄芪桂枝五物汤能有效防治奥沙利铂的周围神经毒性。
英文摘要:
      OBJECTIVE To observe the curative effect of Huangqi Guizhi Wuwu Decoction in the treatment of neuro-sensory toxicity caused by oxaliplatin. METHODS 48 cases of colorectal cancer were randomly divided into the control group (24 cases) treated with chemotherapy alone and the treatment group (24 cases) treated with Huangqi Guizhi Wuwu Decoction additionally. The neuro-sensory toxicity caused by oxaliplatin was judged by Levi standard. RESULTS Among 24 cases in treatment group, 8 cases presentedⅠclass, 1 patientⅡclass, and 0 patients Ⅲ / Ⅳclass, the total occurrence being 79.17%. In the control group, 13 cases presentedⅠclass, 3 patientⅡclass, 3 patients Ⅲ class and 0 case Ⅳclass. Compared with control group, there were less patients got Ⅲ/Ⅳ class toxic reaction in treatment group, which suggested a significant difference (P<0.01). CONCLUSION Huangqi Guizhi Wuwu Decoction has a significant effect on the neuro-sensory toxicity caused by oxaliplatin.
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