文章摘要
司晓晨,夏卫军,尚文斌,程海波.胰敏颗粒胰腺灌流对2型糖尿病IR大鼠胰岛素含量的影响[J].南京中医药大学学报,2008,24(1):31-33.
胰敏颗粒胰腺灌流对2型糖尿病IR大鼠胰岛素含量的影响
Effect of Pancreas Perfusion of Yimin Granule on Insulin Content of IR Rats with Type 2 Diabetes
投稿时间:2007-09-28  修订日期:2007-10-14
DOI:
中文关键词: 2型糖尿病,胰岛素抵抗,胰腺灌流,胰敏颗粒
英文关键词: type 2 diabetes,insulin antagonism,pancreas perfusion,Yimin Granule
基金项目:江苏省科技厅自然科学基金(BK2004152)
司晓晨  夏卫军  尚文斌  程海波
南京中医药大学第一临床医学院 江苏南京210046
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中文摘要:
      目的观察胰敏颗粒对2型糖尿病大鼠胰腺离体灌流胰岛素分泌的影响。方法在链脲佐菌素(STZ)部分破坏大鼠胰岛细胞的基础上,喂养高脂高糖饲料造成大鼠2型糖尿病模型,分离造模大鼠胰腺进行离体灌流,检测胰腺灌流液胰岛素含量。结果在低糖刺激时,胰敏颗粒含药血清对离体胰腺分泌胰岛素无明显影响;在高糖刺激条件下,胰敏颗粒可刺激离体胰腺分泌胰岛素。结论胰敏颗粒对2型糖尿病胰岛分泌缺陷有一定的改善作用。
英文摘要:
      OBJECTIVE To observe the effect of in vitro pancreas perfusion of Yimin Granule on the secretion of insulin in rats with type 2 diabetes.METHOD Rat diabetes models were made by using ATZ to destroy rat insulin cells followed by feeding high-lipid and high-sugar feeding stuff.In vitro pancreas perfusion was performed to detect insulin content.RESULT With low-sugar stimulation,the medicated serum of Yimin Granule did not markedly affect insulin secretion;with high-sugar stimulation,Yimin Granule could promote insulin secretion.CONCLUSION Yimin Granule has certain improving effect on the defect in insulin secretion in type 2 disbetes.
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