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炮制对栀子抗抑郁作用的影响及其机制研究

吴浩然 黄晓燕 孙广达 蒋睿智 单鑫

吴浩然, 黄晓燕, 孙广达, 蒋睿智, 单鑫. 炮制对栀子抗抑郁作用的影响及其机制研究[J]. 南京中医药大学学报, 2020, 36(1): 51-55.
引用本文: 吴浩然, 黄晓燕, 孙广达, 蒋睿智, 单鑫. 炮制对栀子抗抑郁作用的影响及其机制研究[J]. 南京中医药大学学报, 2020, 36(1): 51-55.
WUHao-ran, HUANGXiao-yan, SUNGuang-da, JIANGRui-zhi, SHANXin. Anti-Depressant Effect and Its Mechanism of Gardenia Jasminoides Ellis Before and After Processing[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(1): 51-55.
Citation: WUHao-ran, HUANGXiao-yan, SUNGuang-da, JIANGRui-zhi, SHANXin. Anti-Depressant Effect and Its Mechanism of Gardenia Jasminoides Ellis Before and After Processing[J]. Journal of Nanjing University of traditional Chinese Medicine, 2020, 36(1): 51-55.

炮制对栀子抗抑郁作用的影响及其机制研究

Anti-Depressant Effect and Its Mechanism of Gardenia Jasminoides Ellis Before and After Processing

  • 摘要: 目的 以栀子不同炮制品为研究对象,比较不同炮制品栀子抗抑郁作用及其机制。方法 建立慢性不可预知性应激(CUMS)小鼠模型,并采用栀子不同炮制品水提物干预;给药结束后,采用行为学评价其抗抑郁作用的差异,并探讨其分子学机制。结果 与模型组相比,炒、焦、生栀子组小鼠糖水消耗显著升高(P<0.01);炒、焦栀子明显降低悬尾试验(P<0.05)和强迫游泳试验(P<0.05~0.01)的不动时间,生栀子对以上2者无显著改善;小鼠海马组织中炎性因子白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α),磷酸化核因子-κB(p-NF-κB)(P<0.01)以及胶质纤维酸性蛋白(GFAP)(P<0.01)的表达在造模后显著上升,炮制后栀子(炒、焦)抗炎作用优于生栀子。其中炒栀子抗炎作用最优,IL-β、TNF-α和GFAP均能被炒栀子显著下调(P<0.01)。结论 栀子不同炮制品抗抑郁作用存在差异,其抗抑郁作用差异与其调节小鼠海马组织中炎性因子IL-1β、TNF-α等以及GFAP的表达有关。

     

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  • 刊出日期:  2020-01-10

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