益气明目丸对视网膜色素变性患者眼部血流动力学的影响

蒋鹏飞; 彭俊; 曾志成; 姚小磊; 彭晓芳; 彭清华; 李传课

益气明目丸对视网膜色素变性患者眼部血流动力学的影响

1.
湖南中医药大学眼病与视功能保护中心，湖南长沙 410208
2.
湖南中医药大学第一附属医院，湖南长沙 410007
3.
长沙市中医院眼科，湖南长沙 410100

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出版历程
- 刊出日期: 2020-01-10

Effect of Yiqi Mingmu Pill on Hemodynamics for Retinitis Pigmentosa Patients

1.
Center for Oculopathy and Protecting Visual Function, Hunan University of Chinese Medicine, Changsha, 410208, China
2.
The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China
3.
Ophthalmology Department, Changsha Hospital of Traditional Chinese Medicine, Changsha, 410100, China

摘要

摘要: 目的观察益气明目丸对视网膜色素变性（RP）患者眼部血流动力学的影响。方法采用前瞻性随机对照试验的研究方法，观察2017年10月-2019年1月在湖南中医药大学第一附属医院眼科、长沙市中医院眼科门诊就诊的RP患者70例（140只眼），随机分为治疗组与对照组各35例，分别予以维生素E或益气明目丸口服治疗3月。检测患者的视网膜电图（ERG）、睫状后短动脉收缩期峰值流速（PSV）、舒张末期流速（EDV）、阻力指数（RI）及搏动指数（PI）等进行疗效评价。结果治疗后2组暗适应及明适应ab波振幅、EDV、RI、PI较治疗前有明显改善（P＜0.05），治疗组优于对照组（P＜0.05）。结论益气明目丸能提高RP患者明、暗适应ab波振幅，降低眼部血流阻力，增加视网膜血流量，这可能是益气明目丸治疗RP的机制之一。
- 益气明目丸 /
- 血流动力学 /
- 视网膜色素变性 /
- 视网膜电图
Abstract: OBJECTIVE To observe the effect of Yiqi Mingmu pill on hemodynamics for patients with retinitis pigmentosa (RP). METHODS The prospective randomized control study was applied to observe 70 RP patients (140 eyes) admitted in the First Hospital of Hunan University of Chinese Medicine and Changsha Hospital of Traditional Chinese Medicine， who were randomly divided into the control group (35 cases) and the treatment group (35 cases)， given vitamin E and Yiqi Mingmu pill oral liquid for three months res. The effect analysis was estimated from electroretinogram (ERG)， peak systolic velocity (PSV) of short posterior ciliary arteries， end-diastolic velocity (EDV)， resistance index (RI) and pulsatility index (PI). RESULTS After treatment， indexes of both groups have significantly improved(P<0.05). In the comparison of two groups' ab wave amplitude of dark and light adaptation， EDV， RI and PI， the difference is statistically significant (P<0.05). After two months' and three month's treatment， the difference between patients' PSV in both groups were statistically significant (P<0.05). CONCLUSION Yiqi Mingmu pill can improve RP patients' ab wave amplitude of dark and light adaptation， reduce the ocular blood flow resistance and promote retinal blood flow， which could be the mechanism of Yiqi Mingmu pill treating RP.
- Yiqi Mingmu pill /
- hemodynamics /
- retinitis pigmentosa /
- electroretinogram

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参考文献(21)

[1]	BUNEL M， CHAUDIEU G， HAMEL C， et al. Natural models for retinitis pigmentosa: Progressive retinal atrophy in dog breeds[J]. Hum Genet， 2019， 138(5): 441-453.
[2]	BOCCHERO U， TAM BM， CHIU CN， et al. Electrophysiological changes during early steps of retinitis pigmentosa[J]. Invest Ophth Vis Sci， 2019， 60(4): 933-943.
[3]	HU YS， SONG H， LI Y， et al. Whole-exome sequencing identifies novel mutations in genes responsible for retinitis pigmentosa in 2 nonconsanguineous Chinese families[J]. Int J Ophthalmol， 2019， 12(6): 915.
[4]	王英，蒋鹏飞，潘坤，等.益气明目丸对视网膜色素变性大鼠视网膜Bax、Caspase-3表达的影响[J].眼科新进展，2018，38(11):1019-1023.
[5]	MIYATA M， OISHI A， HASEGAWA T， et al. Concentric choriocapillaris flow deficits in retinitis pigmentosa detected using wide-angle swept-source optical coherence tomography angiography[J]. Invest Ophth Vis Sci， 2019， 60(4): 1044-1049.
[6]	JEPPESEN SK， BEK T. The retinal oxygen saturation measured by dual wavelength oximetry in larger retinal vessels is influenced by the linear velocity of the blood[J]. Curr Eye Res， 2019， 44(1): 46-52.
[7]	赵堪兴，杨培增.眼科学[M].8版.北京:人民卫生出版社，2013:227-228.
[8]	SUGAHARA M， MIYATA M， ISHIHARA K， et al. Optical coherence tomography angiography to estimate retinal blood flow in eyes with retinitis pigmentosa[J]. Sci Rep， 2017， 7(1): 396.
[9]	董玉萍，杨春华，王磊峰，等.手术联合药物治疗视网膜色素变性450例疗效观察[J].山东医药，2011，51(28):103.
[10]	TANG PH， JAUREGUI R， TSANG SH， et al. Optical coherence tomography angiography of RPGR-associated retinitis pigmentosa suggests foveal avascular zone is a biomarker for vision loss[J]. OSLI Retina， 2019， 50(2): e44-e48.
[11]	蒋鹏飞，王英，潘坤，等.益气明目丸对视网膜色素变性大鼠视网膜Bax mRNA、Caspase-3 mRNA表达的影响[J].世界科学技术-中医药现代化，2018，20(10):1834-1839.
[12]	ALNAWAISEH M， SCHUBERT F， HEIDUSCHKA P， et al. Optical coherence tomography angiography in patients with retinitis pigmentosa[J]. Retina， 2019， 39(1): 210-217.
[13]	王肯堂.证治准绳[M].倪和宪，校注.北京:人民卫生出版社，2014:423.
[14]	黄庭镜.目经大成[M].李怀芝，整理.北京:人民卫生出版社，2006:150.
[15]	袁学渊.秘传眼科七十二症[M].北京:中医古籍出版社，2015:112.
[16]	施世德.眼科正宗原机启微[M].王兴伊，刘庆宇，校注.北京:中国中医药出版社，2015:15-16.
[17]	田思胜.中医临床必读丛书合订本·临证各科卷·综合·（六）[M].北京:人民卫生出版社，2011:529.
[18]	宋厚盼，曾梅艳，彭俊，等.枸杞子-丹参药对治疗视网膜色素变性的分子机制探讨[J].中国实验方剂学杂志，2019，25(14):199-206.
[19]	宋厚盼，曾梅艳，彭俊，等.丹参对视网膜色素变性病理过程Müller细胞特征性基因变化及关键蛋白表达的影响[J].中草药，2019，50(8):1863-1872.
[20]	侯晓敏，秦小江.葛根素对大鼠离体冠状动脉血管环的舒张作用及其机制研究[J].中国药物与临床，2014，14(1):36-37.
[21]	蒋鹏飞，王英，潘坤，等.益气明目丸对视网膜色素变性大鼠视网膜Fas、FasL蛋白表达的影响[J].中医杂志，2019，60(4):327-332.