白芥子涂方穴位贴敷防治支气管哮喘的临床研究
Clinical Research on the Prevention and Treatment of Bronchial Asthma by Acupoint Application of Baijiezi Tufang
-
摘要: 目的 观察白芥子涂方穴位贴敷防治支气管哮喘的疗效,以及疗效与皮肤反应之间的关系。方法 所纳入的支气管哮喘患者于三伏天期间进行贴敷,第1年基线期所有患者在(肺俞、心俞、膈俞)对照穴位上进行低剂量药物穴位贴敷,第2年患者随机分为对照组、安慰剂组和试验组,每组30例,对照组继续在对照穴位上进行低剂量药物穴位贴敷,安慰剂组在肺俞、心俞、膈俞进行低剂量药物穴位贴敷,试验组在肺俞、心俞、膈俞进行正常剂量药物穴位贴敷,观察穴位贴敷治疗后患者哮喘发作次数、肺功能以及皮肤反应的变化情况。结果 基线期试验组、安慰剂组、对照组3组患者哮喘发作次数比较,差异无统计学意义。试验期试验组患者哮喘发作次数明显减少,差异具有统计学意义(P<0.01),安慰剂组、对照组患者哮喘发作次数无明显变化,差异无统计学意义。2015年、2016年初伏前比较,3组患者肺功能(MMEF、FEF25、FEF50、FEF75)无明显差异;2017年初伏前,试验组肺功能明显改善(P<0.05~0.01),优于安慰剂组、对照组(P<0.05~0.01)。与基线期穴位贴敷相比,试验期试验组患者贴敷部位皮肤刺激性强度明显增强,差异具有统计学意义(P<0.01),安慰剂组、对照组患者贴敷部位皮肤刺激性强度差异无统计学意义。结论 白芥子涂方穴位贴敷能有效改善哮喘患者的小气道功能,从而减少哮喘的发作,其疗效与贴敷后出现皮肤刺激性反应有关。Abstract: OBJECTIVE To observe the prevention and treatment effect of bronchial asthma by the acupoint application of Baijiezi (Semen Sinapis) tufang, and the relationship between efficacy and skin irritation. METHODS The included bronchial asthma patients were applied during the dog days, all patients in the first year of the baseline stage were given low-dose medicine acupoints application on the control points of Fei shu (BL 13), Xin shu (BL 15), Ge shu (BL 17).In the second year, the patients were randomized into a control group, a placebo group and a experimental group, 30 cases in each one. The control group continued to apply low-dose medicine on the control acupoints, and the placebo group was given low-dose medicine acupoint application on Fei shu(BL 13), Xin shu (BL 15), Ge shu (BL 17). The experimental group were treated with normal does in Fei shu (BL 13), Xin shu (BL 15), Ge shu (BL 17). Observed the changes of asthma attack number, lung function and skin reaction after acupoint application treatment. RESULTS There was no significant difference in the number of asthma attacks between the baseline group, the placebo group and the control group. The number of asthma attacks was significantly reduced in the experimental group, the difference was statistical significant (P<0.01). There was no significant change in the number of asthma attacks between the placebo group and the control group. Compared with the baseline period, there was no significant difference in lung function (MMEF, FEF25, FEF50, FEF75) between the experimental group, the placebo group and the control group before the trial period. Compared with before the baseline period and the trial period, the lung function of the experimental group was significantly improved after the acupoint application treatment, the difference was statistical significant (P<0.05, P<0.01). But the lung function of the placebo group and the control group was not significantly improved, the difference was no statistical significant. Compared with baseline period acupoint application, the skin irritation was significantly enhanced in the experimental group of trial period, the difference was statistical significant (P<0.01).The difference in skin irritation between the placebo group and the control group has no statistical significant. CONCLUSION Baijiezi (Semen Sinapis) tufang acupoint application can effectively improve the small airway function of asthma patients, thus reducing the number of asthma attacks. The treatment effect is related to the skin irritation after the application.
-
Key words:
- Baijiezi tufang /
- acupoint application /
- skin irritation /
- asthma
-
[1] CHEN CL, LI H, XING XH, et al. Effect of TRPV1 gene mutation on bronchial asthma in children before and after treatment[J]. Allergy Asthma Proc, 2015,36(2):e29-36. [2] 张璐.张氏医通[M].上海:上海科学技术出版社,1990:117. [3] 文碧玲,周华,刘保延,等.冬病夏治穴位贴敷疗法防治慢性咳喘穴位处方探析[J].中国针灸,2010,30(8):647-652. [4] 中华医学会呼吸病学分会哮喘学组,中华医学会全科医学分会.中国支气管哮喘防治指南(基层版)[J].中华结核和呼吸杂志,2013,36(5):331-336. [5] 中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社, 2002: 61-66. [6] 中华人民共和国卫生部药政局.中药新药研究指南(药学、药理学、毒理学)[M].北京:人民卫生出版社,1994:209-212. [7] 中国针灸学会.“冬病夏治穴位贴敷”疗法临床应用指导意见(草案) [J].中国针灸,2009,29(7):541-542. [8] 邓亚宁,杨红新,唐敏,等. 三伏平喘贴联合三九止喘贴对不同体质小儿支气管哮喘的疗效观察[J].中国针灸,2017,37(4):386-390. [9] 洪海国,严华,陈汉平,等.化脓灸治疗支气管哮喘若干影响因素的分析[J].上海针灸杂志,1992,11(3):5-6. [10] 陈延之.小品方[M].北京:中国中医药出版社,1995:243. [11] 郭秀彩,刘霞,徐月红.白芥子涂方穴位与非穴位给药皮肤渗透特性的比较研究[J].中国中药杂志,2012,37(7):1034-1038. [12] 吴凌韬,金禹彤,宣丽华.穴位贴敷后不同皮肤反应对治疗支气管哮喘疗效的影响[J].上海针灸杂志,2017,36(3):283-286. [13] 崔淑华,李娜,邢燕军,等.穴位贴敷不同皮肤反应对防治支气管哮喘发作的影响[J].针刺研究,2014,39(3):222-227. [14] 宣丽华,虞彬艳,徐福,等.不同刺激强度穴位贴敷冬病夏治防治支气管哮喘的临床研究[J].中华中医药杂志,2012,27(7):1807-1810. [15] 黄秀香,李淑君,刘鹏珍,等. 支气管哮喘缓解期肺功能的改变[J].临床肺科杂志,2003,8(6):555. [16] 刘成勇,秦珊,刘兰英,等.穴位贴敷对慢性哮喘小鼠气道重塑及转化生长因子β1/Smad3表达的影响[J].针刺研究,2017,42(2):153-158. [17] 刘兰英,乔明,高峰,等. 咳喘停贴剂穴位贴敷对慢性哮喘气道炎症大鼠肺组织T-bet、GATA-3 mRNA表达的影响[J].南京中医药大学学报,2014,30(6):550-553. [18] 耿涛,刘兰英,罗志琴,等.过敏性哮喘患者穴位贴敷后诱发的接触性皮炎皮损处EOS浸润特点[J].中医学报,2017,32(11):2060-2063. [19] 李春雨,任传云,龚容,等. 穴位贴敷治疗哮喘的皮肤反应与临床疗效关系的研究[J].北京中医药大学学报,2012,35(6):430-432. [20] 崔淑华,李娜,邢燕军,等. 白芥子不同配比穴位贴敷防治支气管哮喘的皮肤反应及疗效分析[J].辽宁中医杂志,2014,41(12):2636-2638.
点击查看大图
计量
- 文章访问数: 795
- HTML全文浏览量: 21
- PDF下载量: 743
- 被引次数: 0