Abstract: OBJECTIVE To explore the compatibility of prescription for pulmonary fibrosis. METHODS The literature on the treatment of pulmonary fibrosis (PF) in China National Knowledge Internet (CNKI)， the Chinese Biomedical Literature (CBM) and the Chinese Traditional Medicine Document Retrieval System Database (TCM) from 2005 to 2014 was searched. The "frequency analysis" and "genetic algorithm-oriented analysis of strong biderecrional relevance rule" were used to analysis 182 prescriptions. RESULTS The highest frequency of use is Radix Astragali and other tonifying qi medicinal， followed by Radix et Rhizoma Salviae Miltiorrhizae and other activating blood medicinal. The results of the relevance rule analysis showed that tonifying qi medicinal was more compatible with blood-activating and fortify the spleen medicinal. The flavor of medicine was dominated by sweetness， accompanied with bitterness and pungency， which is high frequency to lung and liver meridian. CONCLUSION The tonifying qi and activating blood medicinal are proved to be the fundamental compatibility for PF therapy in Chinese medicine， there are also more combinations of fortify the spleen and supplement the lung. It means that tonify qi and activate blood， fortify the spleen and supplement the lung are the basic treatment for PF.