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滋肾清肝方对原发性高血压患者动脉功能及炎症因子的影响

李一卓 黄辉 顾万建 刘牛 季明德 吴林琳 栾云 严士海 刘福明

李一卓, 黄辉, 顾万建, 刘牛, 季明德, 吴林琳, 栾云, 严士海, 刘福明. 滋肾清肝方对原发性高血压患者动脉功能及炎症因子的影响[J]. 南京中医药大学学报, 2017, 33(4): 344-348.
引用本文: 李一卓, 黄辉, 顾万建, 刘牛, 季明德, 吴林琳, 栾云, 严士海, 刘福明. 滋肾清肝方对原发性高血压患者动脉功能及炎症因子的影响[J]. 南京中医药大学学报, 2017, 33(4): 344-348.
LI Yi-zhuo, HUANG Hui, GU Wan-jian, LIU Niu, JI Ming-de, WU Lin-lin, LUAN Yun, YAN Shi-hai, LIU Fu-ming. Effects of Zishen Qinggan Formula on Arterial Function and Inflammatory Factors in Patients with Essential Hypertension[J]. Journal of Nanjing University of traditional Chinese Medicine, 2017, 33(4): 344-348.
Citation: LI Yi-zhuo, HUANG Hui, GU Wan-jian, LIU Niu, JI Ming-de, WU Lin-lin, LUAN Yun, YAN Shi-hai, LIU Fu-ming. Effects of Zishen Qinggan Formula on Arterial Function and Inflammatory Factors in Patients with Essential Hypertension[J]. Journal of Nanjing University of traditional Chinese Medicine, 2017, 33(4): 344-348.

滋肾清肝方对原发性高血压患者动脉功能及炎症因子的影响

Effects of Zishen Qinggan Formula on Arterial Function and Inflammatory Factors in Patients with Essential Hypertension

  • 摘要: 目的 通过观察滋肾清肝方对原发性高血压患者动脉功能及血清炎症因子的影响,评价滋肾清肝方的临床疗效。方法 选择符合纳入标准的原发性高血压患者100例,随机分为治疗组及对照组各50例,治疗组予ACEI/ARB+CCB类药物标准治疗基础上联用滋肾清肝方,对照组予ACEI/ARB+CCB类药物,疗程为8周,对比患者治疗前后中医证候积分、颈动脉内膜中层厚度、极速成像脉搏波传导速度、阻力指数、炎症因子、安全性指标的变化。结果 ①2组中医证候积分治疗后均有改善(P<0.01),且治疗组优于对照组(P<0.01);②双侧颈动脉极速脉搏波传导速度、阻力指数(RI)2组治疗后均有改善(P<0.01),其中治疗组优于对照组(P<0.05),双侧颈动脉内膜中层厚度(IMT)2组治疗前后无明显差异(P>0.05);③2组治疗后血清CRP、IL-6、TNF-α水平均有改善(P<0.05),治疗组优于对照组(P<0.05);④2组治疗前后肝肾功能均无统计学意义(P>0.05)。结论 西药ACEI/ARB+CCB基础治疗联合滋肾清肝方对原发性高血压患者动脉弹性功能及炎症因子的改善优于单用ACEI/ARB+CCB基础治疗。

     

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出版历程
  • 收稿日期:  2017-04-14
  • 修回日期:  2017-05-20
  • 刊出日期:  2017-07-10

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