益气养阴通络方治疗早期糖尿病肾病的临床研究
Clinical Research of Yiqi Yangyin Tongluo Formula in Treatment of Early Diabetic Nephropathy
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摘要: 目的 观察益气养阴通络方对早期糖尿病肾病的治疗效果，以期为临床治疗早期糖尿病肾病提供安全、有效的方法。方法 80例早期糖尿病肾病患者按随机数字法分为治疗组42例、对照组38例，对照组给予常规降压降糖治疗，治疗组在对照组治疗基础上服用中药益气养阴通络方治疗，观察2组尿微量白蛋白、24h尿蛋白定量、空腹血糖、糖化血红蛋白、尿β2微球蛋白（β2-MG）及临床有效率。结果 观察组有效率为85.71%，对照组为68.42％，2组比较，差异有统计学意义（P<0.05）；治疗后各组尿微量白蛋白、24h尿蛋白定量、β2-MG比治疗前明显降低（P<0.05~0.01），组间比较，治疗组优于对照组（P<0.05~0.01）。结论 益气养阴通络方治疗早期糖尿病肾病疗效确切，能明显改善患者糖代谢、肾功能，延缓其进展。Abstract: OBJECTIVE To observe therapeutic effects of Yiqi Yangyin Tongluo Formula in treating early diabetic nephropathy， so as to provide a safe and effective method for clinical treatment of early diabetic nephropathy. METHODS Eighty early DN patients were randomly assigned to the treatment group(42 cases) who treated by Yiqi Yangyin Tongluo Formula combined with conventional treatment and the control group(38 cases) treated by conventional treatment. The urine microalbumin， 24-hour urinary protein quantity， fasting blood glucose， glycosylated hemoglobin urine， β2 microglobulin and clinical effective rate of both groups were observed. RESULTS The effective rate was 68.42% in the control group and 85.71% in the treatment group with statistical differences when compared with each other(P<0.05). There experienced an evident decrease in urine microalbumin， 24-hour urinary protein quantity and β2 microglobulin after treatment of the two groups(P<0.05~0.01). And the treatment group was superior to the control group(P<0.05~0.01). CONCLUSION Yiqi Yangyin Tongluo Formula has obvious therapeutic effects on early diabetic nephropathy by improving sugar metabolism， kidney function and prolong its progress.
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