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透明质酸修饰的葛根素PEG-PLGA纳米粒的处方工艺优化及其体外评价

薛瑞 沈晓华 杨洁 李倩

薛瑞, 沈晓华, 杨洁, 李倩. 透明质酸修饰的葛根素PEG-PLGA纳米粒的处方工艺优化及其体外评价[J]. 南京中医药大学学报, 2016, 32(5): 487-490.
引用本文: 薛瑞, 沈晓华, 杨洁, 李倩. 透明质酸修饰的葛根素PEG-PLGA纳米粒的处方工艺优化及其体外评价[J]. 南京中医药大学学报, 2016, 32(5): 487-490.
XUE Rui, SHEN Xiao-hua, YANG Jie, LI Qian. Formulationandprocess Optimization of Puerarin-loaded PEG-PLGA Nanoparticles Modified by Hyaluronic Acid and Its in Vitro Evaluation[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(5): 487-490.
Citation: XUE Rui, SHEN Xiao-hua, YANG Jie, LI Qian. Formulationandprocess Optimization of Puerarin-loaded PEG-PLGA Nanoparticles Modified by Hyaluronic Acid and Its in Vitro Evaluation[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(5): 487-490.

透明质酸修饰的葛根素PEG-PLGA纳米粒的处方工艺优化及其体外评价

Formulationandprocess Optimization of Puerarin-loaded PEG-PLGA Nanoparticles Modified by Hyaluronic Acid and Its in Vitro Evaluation

  • 摘要: 目的 以乳酸-羟基乙酸共聚物(PEG-PLGA)为载体,优化纳米沉淀法制备透明质酸修饰的葛根素PEG-PLGA纳米粒(HA/Pue-NPs),并对其体外性质进行初步评价。方法 以PEG-PLGA为载体材料,透明质酸为表面修饰剂,采用纳米沉淀法制备了透明质酸修饰的HA/Pue-NPs;应用正交实验设计优化处方,对其体外性质进行表征;并采用体外释药行为评价透明质酸修饰HA/Pue-NPs。结果 制备出的载药纳米粒外观呈球形,平均粒径、Zeta电位分别为(88.9±2.2)nm、(-21.9±0.54)mV,载药量及包封率分别为6.75%、78.52%。体外释药试验表明,载药纳米粒释药缓慢,24 h的累计释放率为65.8%。结论 透明质酸修饰的葛根素PEG-PLGA纳米粒粒径大小均一,体外性质良好且具有一定的缓释特性。

     

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出版历程
  • 收稿日期:  2016-03-04
  • 修回日期:  2016-06-25
  • 刊出日期:  2016-09-10

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