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半枝莲提取物中半枝莲碱A和半枝莲碱B大鼠体内药代动力学研究

郭跃龙 郭锦瑞 张磊

郭跃龙, 郭锦瑞, 张磊. 半枝莲提取物中半枝莲碱A和半枝莲碱B大鼠体内药代动力学研究[J]. 南京中医药大学学报, 2016, 32(5): 479-482.
引用本文: 郭跃龙, 郭锦瑞, 张磊. 半枝莲提取物中半枝莲碱A和半枝莲碱B大鼠体内药代动力学研究[J]. 南京中医药大学学报, 2016, 32(5): 479-482.
GUOYue-long, GUOJin-rui, ZHANGLei. Pharmacokinetic Study of Scutebarbatine A and Scutebarbatine B in Rats After Orally Administration of Scutellaria Barbata Extract Using a LC-MS/MS Method[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(5): 479-482.
Citation: GUOYue-long, GUOJin-rui, ZHANGLei. Pharmacokinetic Study of Scutebarbatine A and Scutebarbatine B in Rats After Orally Administration of Scutellaria Barbata Extract Using a LC-MS/MS Method[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(5): 479-482.

半枝莲提取物中半枝莲碱A和半枝莲碱B大鼠体内药代动力学研究

Pharmacokinetic Study of Scutebarbatine A and Scutebarbatine B in Rats After Orally Administration of Scutellaria Barbata Extract Using a LC-MS/MS Method

  • 摘要: 目的 建立同时测定生物样品中半枝莲碱A和半枝莲碱B的LC-MS/MS分析方法,并对其药代动力学进行研究。方法 血浆样品采用乙酸乙酯萃取,BDS Hypersil C18(50 mm×2.1 mm, 2.4 μm)色谱柱进行梯度洗脱,柱温40 ℃,流动相为乙腈:0.05%甲酸水溶液,流速为0.25 mL/min。电喷雾离子源,MRM模式。大鼠单剂量灌胃500 mg/kg半枝莲提取物后,检测半枝莲碱A和半枝莲碱B的血药浓度,DAS软件对其血药浓度-时间曲线进行拟合,统计矩模型计算药动学参数。结果 半枝莲碱A和半枝莲碱B在0.512~258.0 ng/mL和0.482~241.0 ng/mL间线性关系良好(r2>0.994);精密度、准确度、提取回收率和基质效应、稳定性均符合生物样品分析要求。半枝莲碱A和半枝莲碱B的AUC(0-t)分别为(88.69±12.4)μg/L·h和(57.09±9.84) μg/L·h,达峰浓度分别为(10.22±1.31)ng/mL和(6.27±0.80)ng/mL。结论 该方法简便、准确、灵敏,可用于半枝莲提取物中半枝莲碱A和半枝莲碱B体内药代动力学研究。

     

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出版历程
  • 收稿日期:  2016-04-14
  • 修回日期:  2016-07-28
  • 刊出日期:  2016-09-10

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