中医药转化医学研究现状与发展述评
Research Status and Development Review of Translational Medicine of Traditional Chinese Medicine
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摘要: 转化医学作为一种全新的医学理念及实践模式,代表的是当今医学科学发展的重要趋势和必然要求,其倡导基础研究与临床应用之间的双向快速转化。就中医药学与转化医学的相互关系,中药复方在中医药转化医学研究中的作用进行阐述,并围绕如何服务临床转化,提出中药复方基础研究的思路与策略的重点在于中医理论的创新、临床有效药物的开发、疾病防治新机制的发现、复方配伍的机理和规律的阐明。Abstract: Being a brand new medical theory and practice pattern, translational medicine represents the development tendency and inevitable requirement of modern medical science, which emphasizes the two-way rapid transformation between basic research and clinical application. Based on the relationship between traditional Chinese medicine and translational medicine, ideas and strategies for basic research of Chinese herbal compound are put forward by elaborating functions of Chinese herbal compound in translational medicine of traditional Chinese medicine and exploring its proper ways to serve clinical practice, which is not only beneficial to the innovation of traditional Chinese medicine theory and development of new clinical effective medicine, but also conductive to the discovery of new mechanisms and approaches for disease prevention and treatment as well as the illumination of principles and rules for herbal compatibility.
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Key words:
- translational medicine /
- Chinese herbal compound /
- status and development
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[1] CHOI DW. Bench to bedside: the glutamate connection[J]. Science, 1992,258(5080):241-243. [2] GERAGHTY J. Adenomatous polyposis coli and translational medicine[J]. Lancet, 1996,348(9025):422. [3] ZERHOUNI E. The NIH Roadmap[J]. Science, 2003,302(5642):63-72. [4] SARKAR IN. Biomedical informatics and translational medicine[J]. J Transl Med, 2010, 8:22. [5] LITTMAN BH, MARIO LD, PLEBANI M, et al. What's next in translational medicine[J]. Clin Sci, 2007,112(4):217-227. [6] 董尔丹,胡海,洪微.浅析转化医学与医学实践[J].科学通报,2013,58(1):53-62. [7] DONG ED, HU H, HONG W. Exploration on translational medicine and medical practice[J]. Sci Bul, 2013, 58(1): 53-62. [8] 肖小河,王伽伯,鄢丹,等.转化医学:让中药现代化又快又好走进临床[J].中草药, 2012,43(1):1-8. [9] XIAO XH, WANG JB, YAN D, et al. Translational medicine: a better and faster way for modernization of Chinese materia medica to enter clinic[J]. Chin Tradit Herbal Drugs, 2012, 43(1): 1-8. [10] 陈丹霞,汪楠,安佳璐,等.国外转化医学研究发展经验与启示[J].医学分子生物学杂志,2012,9(5):384-387. [11] CHEN DX, WANG N, AN JL, et al. Experience and enlightenment from overseas development of translational medicine[J]. J Med Mol Biol, 2012, 9(5): 384-387. [12] 吴以岭,袁国强,贾振华,等.脉络学说的学术地位及其应用价值[J].中医杂志, 2012,53(1): 3-7. [13] WU YL, YUAN GQ, JIA ZH, et al. Academic position of vessels networks theory and its application[J]. J Tradit Chin Med, 2012, 53(1): 3-7. [14] 张洪春,赵丹,晁燕,等.从苏黄止咳胶囊的研发探讨中药新药选题思路[J].中药新药与临床药理,2009,20(5):485-487. [15] ZHANG HC, ZHAO D, CHAO Y, et al. Thoughts on topic selection of new Chinese herbs from the research and development of Suhuang Zhike Capsule[J]. Tradit Chin Drug Res Clin Pharmacol, 2009, 20(5): 485-487. [16] 程海波,沈卫星,姚志华,等.基于癌毒病机理论的消癌解毒方抗肿瘤研究进展[J].南京中医药大学学报(自然科学版), 2014,30(6):593-595. [17] CHENG HB, SHEN WX, YAO ZH, et al. Research process of Xiaoai Jiedu Formula from its pathogenesis of cancerous toxin[J]. J Nanjing Univ Tradit Chin Med, 2014, 30(6): 593-395. [18] 程海波,沈卫星.癌毒病机理论与炎癌转变[J].中国中西医结合杂志,2015,35(2):243-246. [19] CHENG HB, SHEN WX. Pathogenesis theory of cancerous toxin and transformation between inflammation to carcinoma[J]. Chin J Integr Tradit West Med, 2015, 35(2): 243-246. [20] 沈政洁,程海波,沈卫星,等.肿瘤炎性微环境与“癌毒”病机相关性探讨[J].北京中医药大学学报,2015, 38(1):14-17. [21] SHEN ZJ, CHENG HB, SHEN WX, et al. Correlation between tumor inflammatory micro environment and cancerous toxin pathogenesis[J]. J Beijing Univ Tradit Chin Med, 2015, 38(1): 14-17. [22] 程海波,吴勉华,沈卫星,等.基于癌毒病机理论的癌痛平胶囊治疗癌性疼痛的研究[J].中华中医药杂志,2015,30(12):4371-4374. [23] CHENG HB, WU MH, SHEN WX, et al. Study of Aitongping Capsule on treating cancerous pain based on the pathogenesis theory of cancerous toxin[J]. Chin J Tradit Chin Med Pharm, 2015, 30(12): 4371-4374. [24] 程海波.癌毒病机理论探讨[J].中医杂志,2014,55(20):1711-1714. [25] CHENG HB. Discussion on the pathogenesis theory of cancer toxin[J]. J Tradit Chin Med, 2014, 55(20): 1711-1714. [26] CONTOPOULOS-LOANNIDIS DG, NTZANI E, LOANNIDIS JP. Translation of highly promising basic science research into clinical applications[J]. Am J Med, 2003,114(6):477-484. [27] LEHMANN CU, ALTUWAIJRI MM, LI YC, et al. Translational research in medical informatics or from theory to practice. A call for an applied informatics journal[J]. Methods Inf Med, 2008,47(1):1-3. [28] BUTLER D. Translational research: crossing the valley of death[J]. Nature, 2008, 453(42):840-842. [29] 王阶,郭丽丽,杨戈,等.方剂配伍理论研究方法及研究前景[J].世界科学技术-中医药现代化,2006, 8(1):1-5. [30] WANG J, GUO LL, YANG G, et al. Research method and prospect on compatibility theory of formula[J]. Mod Tradit Chin Med Mater Med-World Sci Technol, 2006, 8(1):1-5. [31] 王喜军,张伯礼.基于药物代谢组学的方剂配伍规律及配伍科学价值揭示.中国中药杂志,2010, 35(10):1346-1348. [32] WANG XJ, ZHANG BL. Elucidation of compatibility principle and scientific value of Chinese medical formula based on pharmacometabolomics[J]. China J Chin Mater Med, 2010, 35(10): 1346-1348.
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