养阴润目丸治疗干眼症的临床观察

李点; 王超群

养阴润目丸治疗干眼症的临床观察

李点,
王超群

湖南中医药大学第一附属医院，湖南长沙 410007

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出版历程
- 刊出日期: 2016-07-10

Clinical Study of Yangyin Runmu Pill for Treating Dry Eye Disease

摘要

摘要: 目的观察养阴润目丸治疗干眼症的临床疗效。方法将120例干眼症患者随机分为2组，各60例。治疗组予养阴润目丸内服，对照组予新泪然滴眼液滴眼，治疗20d比较疗效。结果治疗组和对照组总有效率分别为86.7%和63.3%，差异有统计学意义（P<0.05）；治疗组治疗后泪液分泌量（SIT）明显增多，泪膜破裂时间（BUT）明显延长，与治疗前和同期对照组比较有显著性差异（P<0.01），且治疗组治疗后较对照组角膜染色明显好转（P<0.05~0.01）。结论养阴润目丸可有效改善眼表症状，治疗干眼症疗效确切，值得临床推广应用。
- 养阴润目丸 /
- 干眼症 /
- SIT /
- BUT
Abstract: OBJECTIVE To study the clinical effects of Yangyin Runmu Pill in the treatment of dry eye disease. METHODS 120 cases with dry eye disease were randomly divided into two groups with 60 cases in each group. Patients in the treatment group were treated with oral Yangyin Runmu Pill and those in the control group were given Tears Naturale Forte Eye Drops. And the curative effects of two groups were to be compared after 20 days of treatment. RESULTS The total effective rates of the treatment group and the control group were 86.7% and 63.3% respectively， with a statistical significance(P<0.05). In the treatment group， Schirmer test(SIT) showed an obvious increase of lacrimal secretion and also the tear break-up time(BUT) was extended obviously after treatment， which displayed a significant difference from those before the treatment as well as those in the control group of the same period(P<0.01). The ocular surface staining of the treatment group after treatment was obviously better than that of the control group (P<0.01). CONCULSION Yangyin Runmu Pill can improve ocular surface symptoms effectively and has exact curative effects for dry eye disease， which makes it worthy of clinical application and promotion.
- Yangyin Runmu Pill /
- dry eye disease /
- SIT /
- BUT

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参考文献(16)

[1]	中华医学会眼科学分会角膜病学组．干眼临床诊疗专家共识(2013年)[J]．中华眼科杂志，2013， 49（1）：73-75．
[2]	Corneal Disease Group of Ophthalmological Society of Chinese Medical Association. Expert consensus on clinical diagnosis and treatment of dry eye(2013)[J]. Chin J Ophthalmol， 2013， 49(1):73-75.
[3]	LI J， ZHENG K， DENG Z， et al. Prevalence and risk factors of dry eye disease among a hospital-based population in southeast China[J]. Eye Contact Lens， 2015， 41(1): 44-50.
[4]	李点，廖亮英，胡平，等．养阴润目丸对干眼大鼠结膜上皮细胞中TNF-α及NF-κB表达的影响[J]．中华中医药杂志，2016， 31（2）：678-681．
[5]	LI D， LIAO LY， HU P， et al. Influences of Yangyin Runmu Pill on expression of TNF-α and NF-κB in conjunctival epithelial cells of rats with dry eye[J]. Chin J Tradit Chin Med Pharm， 2016， 31(2) : 678-681.
[6]	COLLIGRIS B， CROOKE A， HUETE-TORAL F， et al. An update on dry eye disease molecular treatment: advances in drug pipelines[J]. Exp Opin Pharm， 2014， 15(10): 1371-1390.
[7]	黄庭镜.目经大成[M].北京:人民卫生出版社，2006:150.
[8]	HUANG TJ. The Great Compendium of Classics on Ophthalmology[M]. Beijing: People's medical publishing house， 2006: 150.
[9]	王朴.生地黄的现代药理研究与临床应用[J].中国中医药现代远程教育，2008，6（8）:986.
[10]	WANG P. Modern pharmacological research and clinical application of raw Radix Et Rhizoma Rhei[J]. Chin Med Mod Dis Edu Chin， 2008， 6(8): 986.
[11]	杨兴斌．当归多糖的组成分析及其激活腹腔巨噬细胞的免疫机制[D]．西安：第四军医大学，2004．
[12]	YANG XB. Composition analysis of angelica polysaccharide and its immunologic mechanism in activating peritoneal macrophages[D]. Xi'an：The Fourth Military Medical University， 2004.
[13]	汪文颖，李金胜．赤芍与白芍的药理作用分析[J]．医学信息，2013， 26（1）：131．
[14]	WANG WY， LI JS. Analysis of pharmacological action of Radix Paeoniae Rubra and Radix Paeoniae Alba[J]. Med Inf， 2013， 26(1): 131.
[15]	李建业，刘运周，张薇，等．北沙参对小鼠免疫功能的影响研究[J]．中国实验诊断学，2012， 16（9）：1599-1601．
[16]	LI JY， LIU YZ， ZHANG W， et al. Influence of Radix Glehniae on mice immunity function[J]. Chin J Lab Diag， 2012， 16(9): 1599-1601.