益气养阴法联合吉西他滨对老年晚期非小细胞肺癌生活质量的影响

陈黎; 李红; 邱婷; 吴峰妹; 张颖; 蔡敏

益气养阴法联合吉西他滨对老年晚期非小细胞肺癌生活质量的影响

南京中医药大学附属昆山市中医医院，江苏昆山 215300

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- 刊出日期: 2016-07-10

Influences of Reinforcing Qi and Nourishing Yin Method Combined with Gemcitabine on Quality of Life of Senile Patients with Advanced Non-small Cell Lung Cancer

摘要

摘要: 目的观察中医益气养阴法联合吉西他滨化疗，对老年晚期非小细胞肺癌（NSCLC）生活质量、免疫功能等的影响。方法 60例老年晚期NSCLC患者，随机分为治疗组31例（益气养阴抗瘤方联合吉西他滨）和对照组29例（吉西他滨），记录2组患者观察期间生活质量、临床症状、化疗毒副反应、免疫功能等变化。结果治疗后治疗组躯体功能、角色功能、整体生活质量评分均高于对照组(P<0.01)；治疗组呼吸困难、失眠、食欲丧失等症状评分低于对照组(P<0.05~0.01)；咳嗽、气短、口干咽燥等症状缓解明显优于对照组（P<0.01）;治疗组血清免疫功能部分改善，与对照组相比，P<0.01；治疗组化疗不良反应低于对照组(P<0.05)。结论中医益气养阴治法联合吉西他滨化疗能有效治疗老年晚期NSCLC，改善临床症状，提高生活质量，减少治疗中的不良反应。
- 非小细胞肺癌 /
- 老年晚期 /
- 益气养阴法 /
- 化疗 /
- 生活质量
Abstract: OBJECTIVE To observe the influences of reinforcing qi and nourishing yin method combined with gemcitabine on immunologic function and quality of life in senile patients with advanced non-small cell lung cancer(NSCLC). METHODS 60 senile patients with advanced NSCLC were randomly divided into treatment group(31 cases treated with Yiqi Yangyin Kangliu Formula plus gemcitabine) and control group(29 cases given gemcitabine only). Such changes as quality of life， clinical symptoms， adverse reaction of chemotherapy and immunologic function of both groups during the observation period were recorded. RESULTS After treatment， body function scores， role function scores as well as the overall quality of life scores of patients in the treatment group were much higher than those in the control group(P<0.01). And such symptom scores as dyspnea， insomnia， loss of appetite in the treatment group were much lower than those in the control group(P<0.05~0.01). Symptoms like cough， shortness of breath， dry mouth and throat were reduced obviously， which were superior to control group(P<0.01). Compared to the control group， there were partial improvements of serum immune function in the treatment group(P<0.01); And adverse reaction of chemotherapy in the treatment group was lower than that in the control group(P<0.05). CONCULSION Reinforcing qi and nourishing yin method combined with gemcitabine is effective in treating senile patients with advanced NSCLC by improving clinical symptoms and quality of life and reducing side effects caused by treatment.
- non-small cell lung cancer(NSCLC) /
- advanced-stage in elderly /
- reinforcing qi and nourishing yin method /
- chemotherapy /
- quality of life

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参考文献(10)

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