通便汤对慢传输便秘模型的药效学研究

徐天舒; 钱海华; 周青; 孟军

通便汤对慢传输便秘模型的药效学研究

1.
南京大学医学院附属鼓楼医院，江苏南京 210008
2.
南京中医药大学附属医院，江苏南京 210029
3.
连云港市中医院肛肠科，江苏连云港 222001

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出版历程
- 刊出日期: 2016-01-10

Pharmacodynamic Effects of Tongbian Decoction on Slow Transit Constipation Model

1.
Gulou Hospital Affiliated to Medical College of Nanjing University, Nanjing, 210008, China
2.
The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China
3.
Anorectal Department, Lianyungang Traditional Chinese Medicine Hospital, Lianyungang, 222001, China

摘要

摘要: 目的观察通便汤对慢传输型便秘大鼠模型的影响，探讨其通便机制。方法随机将SD大鼠分为正常对照组及造模组。正常对照组给予蒸馏水灌胃，造模组采用泻剂结肠法造模；模型成功后，造模组大鼠随机分为模型对照组、莫沙必利组、通便汤组。在运用药物干预的第2、4、6周分别进行结肠内存留粪便粒数、碳末推进率、结肠肌电试验、结肠Cajal间质细胞（ICC）形态学观察。结果通便汤能显著缓解功能性便秘大鼠的便秘症状，增强大鼠结肠组织的收缩幅度、促进肠蠕动，改善受损的肠组织细胞，较模型对照组具有明显优势（P<0.01）。结论通便汤方具有确切的促进慢传输型便秘大鼠结肠传输功能的作用。
- 通便汤 /
- 慢传输型便秘 /
- Cajal间质细胞 /
- 结肠肌电试验
Abstract: OBJECTIVE To observe the effect and mechanism of Tongbian Decoction on slow transit constipation Model. METHODS SD rats were divided into normal control group and model group. Normal control group were given distilled water， while the model group was treated by laxative colon method and divided into natural recovery group， mosapride groups and Tongbian Decoction soup. After the drug intervention of 2， 4 and 6 weeks， dejection amounts in colon， the rate of carbon powder proposed， colonic electrical test and the morphological observation of colon interstitial cells of Cajal (ICC) were measured. RESULTS Compared to natural recovery group，Tongbian Decoction group significantly alleviated the constipation symptoms of functional constipated rats， enhanced the contraction of colon tissue， promoted intestinal peristalsis and improved the damaged intestinal tissue cells (P<0.01). CONCLUSION Tongbian Decoction can promote the colonic transit activities of slow transit constipation model rats.
- Tongbian Decoction /
- slow transit constipation /
- interstitial cells of Cajal /
- colonic electrical test

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参考文献(11)

[1]	Lino S， Horiguchi S， Horiguchi K. Interstitial cells of Cajal in the gastrointestinal musculature of W(jic) c-kit mutant mice[J]. J Smooth Muscle Res， 2011， 47(3/4): 111-121.
[2]	张荣枝，杨光，钱海华.通便汤治疗便秘的临床对照观察[J]．湖北中医药大学学报，2014， 16（4）：80-82．
[3]	Zhang RZ， Yang G， Qian HH. Controlled clinical observation of Tongbian Decoction in treatment of constipation[J]．J Hubei Univ Chin Med，2014， 16（4）：80-82．
[4]	黄显凯，胥基太，童卫东．“泻剂结肠”大鼠的结肠肌电生理变化及其意义[J]．中国普外基础与临床杂志，2003， 10（1）：28-29， 32．
[5]	Huang XK， Xu JT， Tong WD. The change of electromyophysiology of the rat with cathartic colon[J]. Chin J Bases Clin General Surg， 2003， 10(1): 28-29， 32.
[6]	李仪奎．中药药理实验方法学[M]．上海：上海科学技术出版社，1991：925．
[7]	Li YK. Experiment Methodology of Traditional Chinese Medicine Pharmacology[M]．Shanghai：Shanghai scientific and technical publishers，1991：925．
[8]	Camilleri M， Bharucha AE， Di Lorenzo C， et al. American neurogastroenterology and motility society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice[J]. Neurogastroenterol Motil， 2008， 20(12): 1269-1282.
[9]	丁超，顾红，陈玉根，等．“养阴润肠方”用药分析及其治疗慢传输型便秘药理学探究[J]．辽宁中医杂志，2014， 41（11）：2329-2331．
[10]	Ding C， Gu H， Chen YG， et al. Analysis on Yangyin Runchang formula and its pharmacy on treating STC[J]. Liaoning J Tradit Chin Med， 2014， 41(11): 2329-2331.
[11]	Waitzberg DL， Logullo LC， Bittencourt AF， et al. Effect of synbiotic in constipated adult women：a randomized， double-blind， placebo-controlled study of clinical response[J]. Clin Nutr， 2013， 32(1): 27-33.