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针刺联合康复训练对MCAO大鼠内源性神经干细胞增殖的影响

胡科 任应国 徐明超 张保朝 贾东佩

胡科, 任应国, 徐明超, 张保朝, 贾东佩. 针刺联合康复训练对MCAO大鼠内源性神经干细胞增殖的影响[J]. 南京中医药大学学报, 2016, 32(1): 50-53.
引用本文: 胡科, 任应国, 徐明超, 张保朝, 贾东佩. 针刺联合康复训练对MCAO大鼠内源性神经干细胞增殖的影响[J]. 南京中医药大学学报, 2016, 32(1): 50-53.
HU Ke, REN Ying-guo, XU Ming-chao, ZHANG Bao-chao, JIA Dong-pei. Effects of Acupuncture Combined with Rehabilitation Training on Neurological Deficits and Endogeneous Nerve Stem Cells in Adult Rats with Brain Ischemic Injury[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(1): 50-53.
Citation: HU Ke, REN Ying-guo, XU Ming-chao, ZHANG Bao-chao, JIA Dong-pei. Effects of Acupuncture Combined with Rehabilitation Training on Neurological Deficits and Endogeneous Nerve Stem Cells in Adult Rats with Brain Ischemic Injury[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(1): 50-53.

针刺联合康复训练对MCAO大鼠内源性神经干细胞增殖的影响

Effects of Acupuncture Combined with Rehabilitation Training on Neurological Deficits and Endogeneous Nerve Stem Cells in Adult Rats with Brain Ischemic Injury

  • 摘要: 目的 探讨针刺联合康复治疗对成年局灶性脑缺血大鼠的神经功能缺损评分及内源性神经干细胞增殖的影响。方法 制备大脑中动脉阻塞(MCAO)模型,并将其分为模型组、康复训练组及针康组,分别于造模后24 h、7 d、14 d、21 d进行神经功能评定和行为功能评估,同时应用Brdu免疫组化法观察再灌注损伤后大鼠神经干细胞增殖情况。结果 3组大鼠治疗后24 h神经功能评定及行为功能评估比较差异无统计学意义;随着时间的推移,第7、14、21天针康组和康复组神经功能评定及行为功能评估与模型组比较,差异有统计学意义(P<0.05),且与治疗前比较,各组内治疗后第7天、第14天、第21天差异有统计学意义(P<0.05)。第7天针康组和康复组Brdu阳性细胞数与模型组比较,差异有统计学意义(P<0.05)。治疗后第7天与第14天、第21天Brdu阳性细胞数比较差异有统计学意义(P<0.05)。结论 针刺加康复训练均能增加成年局灶性脑缺血大鼠的神经功能及内源性神经干细胞的增殖。

     

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  • 刊出日期:  2016-01-10

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