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甘草泻心汤对溃疡性结肠炎患者血浆IL-17、IL-23水平的影响

王国庆 魏文红 杨杰

王国庆, 魏文红, 杨杰. 甘草泻心汤对溃疡性结肠炎患者血浆IL-17、IL-23水平的影响[J]. 南京中医药大学学报, 2016, 32(1): 25-28.
引用本文: 王国庆, 魏文红, 杨杰. 甘草泻心汤对溃疡性结肠炎患者血浆IL-17、IL-23水平的影响[J]. 南京中医药大学学报, 2016, 32(1): 25-28.
WANG Guo-qing, WEI Wen-hong, YANG Jie. Effects of Gancao Xiexin Decoction on Serum Levels of IL-17 and IL-23 in Patients with Ulcerative Colitis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(1): 25-28.
Citation: WANG Guo-qing, WEI Wen-hong, YANG Jie. Effects of Gancao Xiexin Decoction on Serum Levels of IL-17 and IL-23 in Patients with Ulcerative Colitis[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(1): 25-28.

甘草泻心汤对溃疡性结肠炎患者血浆IL-17、IL-23水平的影响

Effects of Gancao Xiexin Decoction on Serum Levels of IL-17 and IL-23 in Patients with Ulcerative Colitis

  • 摘要: 目的 观察甘草泻心汤对溃疡性结肠炎(UC)患者血浆白介素17(IL-17)、白介素23(IL-23)水平的影响,探讨甘草泻心汤治疗UC的可能机制。方法 将60例UC患者随机分为对照组及治疗组各30例,对照组予以柳氮磺吡啶口服治疗,治疗组在对照组的基础上配合甘草泻心汤治疗,疗程8周。观察治疗前后临床症状的改善情况,进行临床疗效评定,采用Mayo评分系统评估疾病活动度,采用IBDQ量表进行生活质量评分。同时采集2组患者外周静脉血,应用酶联免疫吸附法(ELISA)检测IL-17、IL-23的水平。结果 治疗组临床疗效总有效率达93.3%,明显优于对照组(总有效率80%,P<0.05);治疗后2组Mayo评分均下调(P<0.01),治疗组评分明显低于对照组(P<0.01);2组IBDQ评分均升高(P<0.05~0.01),治疗组IBDQ量表中肠道症状、全身症状、情感功能、社会功能及总分均高于对照组(P<0.05~0.01)。治疗后,UC患者血浆IL-17、IL-23均下调(P<0.01),与对照组相比,治疗组的IL-17、IL-23下调更显著(P<0.01)。结论 甘草泻心汤联合柳氮磺吡啶治疗UC,可显著改善临床症状,提高生活质量;甘草泻心汤下调UC患者血浆IL-17、IL-23水平,参与免疫调节,可能是其治疗本病的机制之一。

     

  • [1] Stritesky GL,Yeh N,Kaplan MH. IL-23 promotes maintenance but not commitment to the th17 lineage[J].J Immunol,2008,181(9):5948-5955.
    [2] McGeachy MJ,Chen Y,Tato CM,et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo[J].Nat Immunol,2009,10(3):314-324.
    [3] 中华医学会消化病学分会炎症性肠病学组. 炎症性肠病诊断与治疗的共识意见(2012年·广州)[J].中华内科杂志,2012,51(10):818-831.
    [4] Inflammatory Bowel Epidemiology Division, Chinese Society of Gastroenterology. Consensus on diagnosis and treatment of inflammatory bowel disease in Guangzhou 2012[J]. Chin J Intern Med, 2012, 51(10):818-831.
    [5] Guyatt G,Mitchell A,Irvine EJ,et al.A new measure of health status for clinical trials in inflammatory bowel disease[J].Gastroenterol,1989,96(3):804-810.
    [6] Fujino S,Andoh A,Bamba S,et al.Increased expression of interleukin17 in inflammatory bowel disease[J].Gut,2003,52(1):65-70.
    [7] 姚宏凤,沈洪.溃疡性结肠炎患者血浆及肠黏膜组织中IL-23、IL-17的表达及相互关系[J].世界华人消化杂志,2013,(29):3153-3157.
    [8] Yao HF, Shen H. Expression of IL-23 and IL-17 in plasma and colonic mucosal on patients with ulcerative colitis and its mutual relation[J]. World Chin J Dig, 2013,(29):3153-3157.
    [9] 郑波,闵小彦,裴继华,等.血浆白细胞介素23和白细胞介素17水平与溃疡性结肠炎的相关性研究[J].中国医师进修杂志,2015,38(3):222-224.
    [10] Zheng B, Min XY, Pei JH, et al. Relevant research between serum levels of interleukin-23 and interleukin-17 and ulcerative colitis[J]. Chin J Postgrad Med, 2015,38(3): 222-224.
    [11] 宁屹.甘草泻心汤对溃疡性结肠炎大鼠IL-8、I-kB的影响[D].福州:福建中医药大学,2014.
    [12] Ning Y. Effects of Gancao Xiexin decoction on IL-8, I-KB in rats with ulcerative colitis[D]. Fuzhou: Fujian University of Traditional Chinese Medicine, 2014.
    [13] 曾毅龙.甘草泻心汤对溃疡性结肠炎大鼠IL-10、NF-κB的影响[D].福州:福建中医药大学,2014.
    [14] Zeng YL. Effects of Gancao Xiexin decoction on IL-10, NF-κB in rats with ulcerative colitis[D]. Fuzhou: Fujian University of Traditional Chinese Medicine, 2014.
    [15] 孙劲松,汤学夫.甘草泻心汤加味治疗溃疡性结肠炎的临床研究[J].中医临床研究,2014,6(19):57-58.
    [16] Sun JS, Tang XF. Clinical research on modified Gancao Xiexin decoction in treating ulcerative colitis[J]. Clin J Tradit Chin Med, 2014, 6(19):57-58.
    [17] 赵秋枫,王实,夏亮,等.甘草泻心汤治疗复发性溃疡性结肠炎临床研究[J].中国中西医结合消化杂志,2013,21(3):133-136.
    [18] Zhao QF, Wang S, Xia L, et al. Clinical research on Gancao Xiexin decoction in treating recurrent ulcerative colitis[J]. Chin J Integr Tradit West Med Dig, 2013, 21(3):133-136.
    [19] 刘伟,陈诗华,罗刚.美沙拉嗪与柳氮磺吡啶用于溃疡性结肠炎患者的疗效对比分析[J].抗感染药学,2015,12(1):125-126.
    [20] Liu W, Chen SH, Luo G. Contrastive analysis of effects of mesalazine and sulfasalazine in treating ulcerative colitis[J]. Anti-Infection Pharm, 2015, 12(1) :125-126.
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  • 刊出日期:  2016-01-10

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