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人参皂苷Rb1在体外肠道菌群模型中的代谢研究

钱静 康安 狄留庆 狄亚维 李杰

钱静, 康安, 狄留庆, 狄亚维, 李杰. 人参皂苷Rb1在体外肠道菌群模型中的代谢研究[J]. 南京中医药大学学报, 2015, 31(6): 567-570.
引用本文: 钱静, 康安, 狄留庆, 狄亚维, 李杰. 人参皂苷Rb1在体外肠道菌群模型中的代谢研究[J]. 南京中医药大学学报, 2015, 31(6): 567-570.
QIANJing, KANGAn, DILiu-qing, DIYa-wei, LIJie. Research on the Metabolism of Ginsenoside Rb1 by Intestinal Flora under Anaerobic and Aerobic Conditions in vitro[J]. Journal of Nanjing University of traditional Chinese Medicine, 2015, 31(6): 567-570.
Citation: QIANJing, KANGAn, DILiu-qing, DIYa-wei, LIJie. Research on the Metabolism of Ginsenoside Rb1 by Intestinal Flora under Anaerobic and Aerobic Conditions in vitro[J]. Journal of Nanjing University of traditional Chinese Medicine, 2015, 31(6): 567-570.

人参皂苷Rb1在体外肠道菌群模型中的代谢研究

Research on the Metabolism of Ginsenoside Rb1 by Intestinal Flora under Anaerobic and Aerobic Conditions in vitro

  • 摘要: 目的 研究人参皂苷Rb1在厌氧和有氧条件下经肠道菌群作用下逐级脱糖基的代谢差异。方法 利用UPLC-MS/MS研究人参皂苷Rb1在厌氧和有氧条件下经肠菌液的作用下,分别温孵0、2、4、8、12、24、48、72 h后,人参皂苷Rb1及其脱糖基代谢物的变化情况。结果 体外温孵实验中,人参皂苷Rb1在厌氧和有氧条件下经大鼠肠菌液作用下脱糖基生成人参皂苷Rd、F2、C-K,其中Rd→F2是Rb1在肠菌液的作用下脱糖基代谢的限速步骤。人参皂苷Rb1在大鼠肠道菌群作用下代谢途径为Rb1→Rd→F2→C-K。结论 人参皂苷Rb1在有氧和厌氧条件下脱糖基代谢产物没有差异,有氧代谢速率快于厌氧代谢。

     

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  • 刊出日期:  2015-11-10

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