中药辨证与α-1b干扰素防治手足口病的临床研究

杨海英; 王明月; 张全发; 徐曼曼; 牟春笋

中药辨证与α-1b干扰素防治手足口病的临床研究

1.
山东中医药大学第二附属医院，山东济南 250001
2.
成武县人民医院儿科，山东成武 274200
3.
菏泽市中医医院儿科，山东菏泽 274000

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出版历程
- 刊出日期: 2014-01-10

Clinical Research on the Preventive effects of traditional Chinese medicine formula and Interferon α-1b on Hand-foot-and-mouth Disease

1.
Department of Pediatrics, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250001, China
2.
Department of Pediatrics, Chengwu Country People's Hospital, Chengwu, 274200, China
3.
Department of Pediatrics Heze City Hospital of Traditional Chinese Medicine, Heze, 274000, China

摘要

摘要: 目的观察中药辨证与α-1b干扰素防治手足口病的效果，进一步探讨适合山东地区的手足口病预防方案。方法 2010年4月-2012年10月期间，在手足口病流行季节发病集中地区，选择符合纳入标准的儿童1106例，随机分为4组，即预防1组（中药组）、预防2组（中药+干扰素组）、预防3组（干扰素组）、对照组（空白对照），进行预防观察，疗程7d。投药后观察随访4周，统计普通病例和重症病例数，记录不良反应，比较各组儿童发病率及重症病例发病率。结果中药组、中药+干扰素组、干扰素组、对照组的发病率分别为 8.02%、11.98%、9.92%、 36.46%，各预防组与对照组比较有显著性差异，均为P＜0.01，各预防组之间发病率比较差异无统计学意义，P＞0.05。各预防组效果指数分别为4.55、3.06、3.68，保护效价分别为78.00%、67.14%、72.79%。预防组平均发病率为9.78%，其中重症病例占6.25%（5/80）；对照组发病率为36.46%，其中重症病例占17.14%（18/105），2组比较，P<0.05，预防组未见明显不良反应。结论中药辨证与α-1b干扰素预防用药均能显著降低手足口病发病率及重症病例发病率。
- 手足口病 /
- 预防 /
- 中药 /
- 重组人干扰素α-1b
Abstract: OBJECTIVE To investigate the preventive effect of traditional Chinese medicine TCM and interferon (IFN) on children with hand-foot-and-mouth disease (HFMD)， and to provide scientific TCM recipe and integrated traditional prevention guideline for HFMD in Shandong province. MRTHODS During April 2010 and October 2012's hand-foot-and-mouth disease epidemic seasons， 1106 cases children from the disease focus areas were chosen and randomly divided into four groups: prevention group 1 (TCM group); prevention group 2 (TCM +IFN group); prevention group 3 (IFN group) and control group (Blank control group). The course of treatment is 7 days， every case has been followed-up for 4 weeks. The normal and severe cases were counted， adverse reactions were recorded， and each groups' incidence of HFMD and severe cases were compared. RESULTS The incidences of HFMD in the four groups are separately 8.02%， 11.98%， 9.92% and 36.46%. There is significant difference between every preventive group and control group (all P<0.01). There is no statistical difference between the former three preventive groups (P>0 05). The effective index of preventive groups are separately 4.55， 3.06， 3.68; the protective efficacy of the three groups are separately 78.00%， 67.14%， 72.79%. The average incidence of prevention groups is 9.78%， and severe cases accounted for 6.25% (5/80). The incidence of control group is 36.46%， and severe cases accounted for 17.14% (18/105). CONCLUSION The traditional Chinese medicine and interferon can significantly reduce the incidence of hand-foot-and-mouth disease and the incidence of severe cases.
- hand-foot-and-mouth disease /
- prevention /
- traditional Chinese medicine /
- interferon α-1b

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参考文献(4)

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