补肾活血化痰方联合阿托伐他汀钙对动脉粥样硬化兔斑块炎性因子的影响
Intervention Study on Inflammatory Factors of Rabbits with Atherosclerosis by Reinforcing the Kidney， Promoting Blood and Resolving Phlegm
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摘要: 目的 研究补肾活血化痰法对动脉粥样硬化（AS）斑块炎性因子的影响机制。方法 将健康新西兰大白兔40只随机分为模型对照组(MG)，中药组(TCMG)，西药组(WMG)，中西药结合组（ZXG)。采用ELISA等方法观察治疗前后各组动物5个炎性因子水平（包括纤维蛋白原(fibrinogen，Fg)、高敏C-反应蛋白(hypersensitive C-reaction protein， hs-CRP)、白介素-18(interleukin-18，IL-18)、单核细胞趋化蛋白-1(Monocyte chemotactic protein-1，MCP-1)、基质金属蛋白酶-9(matrix metalloproteinase-9，MMP-9）。结果 治疗后组间比较，与MG组比较，TCMG组、WMG组及ZXG组5种炎性因子指标均显著降低(P<0.01)；ZXG组在降低5种炎性因子指标水平方面，疗效明显优于单纯TCMG组或WMG组(P<0.01)；而TCMG组与WMG组比较，WMG组在降低hs-CRP方面，疗效优于TCMG组(P<0.05)。 结论 补肾活血化痰法联合阿托伐他汀钙治疗可显著降低AS家兔炎性因子水平，炎性因子水平高低可能是决定AS斑块易损性的重要因素之一。Abstract: OBJECTIVE The study investigates the mechanism of the inflammatory factors of the atherosclerosis' (AS) plaques of experimental rabbit models by therapy of tonifying the kidney and activating blood and dissipating phlegm， and to discuss the advantages of combination of TCM with western medicine in the treatment of AS.METHODS The study selected 40 healthy male purebred rabbits of New Zealand， 2 weeks after feeding observation adaptability， all rabbits were randomly divided into 4 groups， Model Group(MG)，Traditional Chinese Medicine Group (TCMG)，West Medicine Group(WMG)， Zhong Xi Group(ZXG).After the treatment， three treatment groups' rabbits were observed on the levels of the blood lipid and lipoprotein， and five serum inflammatory factors（including Fg，hs-CRP，IL-18，MCP-1，MMP-9）.RESULTS Compared between each treatment groups， with MG， the level of the five inflammatory factors of the three treatment groups declined significantly(P<0.01).The group of ZXG was superior to the groups of TCMG and WMG in decreasing the level of five inflammatory factors(P<0.01).And compared with TCMG， the group of WMG was superior to the TCMG in decreasing the level of the hs-CRP(P<0.05)，but the other four indicators had no differences(P＞0.05).CONCLUSION The therapy of tonifying the kidney and activating blood and dissipating phlegm combined with the Atorvastatin calcium may be superior to the groups of TCMG and WMG in decreasing the levels of five inflammatory factors. We can infer that the levels of inflammatory factors may be a important element to decide plaque vulnerability.
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